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2015/11/10

Scientific Reports Table of Contents e-alert: 10 November 2015

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  10 November 2015   
 
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Flexible navigation response in common cuckoos Cuculus canorus displaced experimentally during migration

 
 

Mikkel Willemoes, Julio Blas, Martin Wikelski et al.

 
 

Migrating birds follow innate species-specific migration programs capable of guiding them along complex spatio-temporal routes, which may include several separate staging areas. …

 
 
 
 
 
 

Superinfection exclusion is absent during acute Junin virus infection of Vero and A549 cells

 
 

Raphaël Gaudin, Tomas Kirchhausen

 
 

Many viruses have evolved strategies of so-called “superinfection exclusion” to prevent re-infection of a cell that the same virus has already infected. Although Old World …

 
 
 
 
 
 

Deciphering Supramolecular Structures with Protein-Protein Interaction Network Modeling

 
 

Toshiyuki Tsuji, Takao Yoda, Tsuyoshi Shirai

 
 

Many biological molecules are assembled into supramolecules that are essential to perform complicated functions in the cell. However, experimental information about the …

 
 
 
 
 
 

Urinary neopterin, a non-invasive marker of mammalian cellular immune activation, is highly stable under field conditions

 
 

Michael Heistermann, James P. Higham

 
 

Studying immunity and immune function in ecology and evolution requires field studies, but there has been a dearth of non-invasive markers of immune activation available for …

 
 
 
 
 
 

The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes

 
 

Xiaoming Zhang, Luru Dai, Anhe Wang et al.

 
 

Highly dynamic tubular structures in cells are responsible for exchanges between organelles. Compared with bacterial invasion, the most affordable and least toxic lipids were …

 
 
 
 
 
 

TIMP-1 mediates TGF-β-dependent crosstalk between hepatic stellate and cancer cells via FAK signaling

 
 

Sang-A Park, Min-Jin Kim, So-Yeon Park et al.

 
 

Transforming growth factor-β (TGF-β) signaling plays a key role in progression and metastasis of HCC. This study was undertaken to gain the proof of concept of a small-molecule …

 
 
 
 
 
 

Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism

 
 

Motoko Maekawa, Yoshimi Iwayama, Tetsuo Ohnishi et al.

 
 

The solute carrier 27A (SLC27A) gene family encodes fatty acid transport proteins (FATPs) and includes 6 members. During fetal and postnatal periods of development, the growing …

 
 
 
 
 
 

Muscle tissue engineering and regeneration through epigenetic reprogramming and scaffold manipulation

 
 

S.J. Tan, J.Y. Fang, Y. Wu et al.

 
 

Efficiency of cell-based tissue engineering and regenerative medicine has been limited by inadequate cellular responses to injury because of aging and poor controllability of …

 
 
 
 
 
 

Cultural traditions across a migratory network shape the genetic structure of southern right whales around Australia and New Zealand

 
 

E. L. Carroll, C. S. Baker, M. Watson et al.

 
 

Fidelity to migratory destinations is an important driver of connectivity in marine and avian species. Here we assess the role of maternally directed learning of migratory …

 
 
 
 
 
 

A metabolomics study delineating geographical location-associated primary metabolic changes in the leaves of growing tobacco plants by GC-MS and CE-MS

 
 

Yanni Zhao, Jieyu Zhao, Chunxia Zhao et al.

 
 

Ecological conditions and developmental senescence significantly affect the physiological metabolism of plants, yet relatively little is known about the influence of geographical …

 
 
 
 
 
 

Forager bees (Apis mellifera) highly express immune and detoxification genes in tissues associated with nectar processing

 
 

Rachel L. Vannette, Abbas Mohamed, Brian R. Johnson

 
 

Pollinators, including honey bees, routinely encounter potentially harmful microorganisms and phytochemicals during foraging. However, the mechanisms by which honey bees manage …

 
 
 
 
 
 

The Biarzo case in northern Italy: is the temporal dynamic of swine mitochondrial DNA lineages in Europe related to domestication?

 
 

Stefania Vai, Sibelle Torres Vilaça, Matteo Romandini et al.

 
 

Genetically-based reconstructions of the history of pig domestication in Europe are based on two major pillars: 1) the temporal changes of mitochondrial DNA lineages are related …

 
 
 
 
 
 

Bats and Rodents Shape Mammalian Retroviral Phylogeny

 
 

Jie Cui, Gilda Tachedjian, Lin-Fa Wang

 
 

Endogenous retroviruses (ERVs) represent past retroviral infections and accordingly can provide an ideal framework to infer virus-host interaction over their evolutionary …

 
 
 
 
 
 

Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice

 
 

Jian-Hua Mao, Sasha A. Langley, Yurong Huang et al.

 
 

Evidence has emerged that suggests a link between motor deficits, obesity and many neurological disorders. However, the contributing genetic risk factors are poorly understood. …

 
 
 
 
 
 

Size does matter: 18 amino acids at the N-terminal tip of an amino acid transporter in Leishmania determine substrate specificity

 
 

Doreen Schlisselberg, Eldar Mazarib, Ehud Inbar et al.

 
 

Long N-terminal tails of amino acid transporters are known to act as sensors of the internal pool of amino acids and as positive regulators of substrate flux rate. In this study …

 
 
 
 
 
 

Multimodal super-resolution optical microscopy visualizes the close connection between membrane and the cytoskeleton in liver sinusoidal endothelial cell fenestrations

 
 

Viola Mönkemöller, Cristina Øie, Wolfgang Hübner et al.

 
 

Liver sinusoidal endothelial cells (LSECs) act as a filter between blood and the hepatocytes. LSECs are highly fenestrated cells; they contain transcellular pores with diameters …

 
 
 
 
 
 

Chronic Stress Alters Spatial Representation and Bursting Patterns of Place Cells in Behaving Mice

 
 

Mijeong Park, Chong-Hyun Kim, Seonmi Jo et al.

 
 

Chronic uncontrollable stress has been shown to produce various physiological alterations and impair mnemonic functions in the rodent hippocampus. Impacts on neuronal activities, …

 
 
 
 
 
 

Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2)

 
 

Andre Madsen, Olivera Bozickovic, Jan-Inge Bjune et al.

 
 

The ability of the anti-diabetic drug metformin to inhibit anabolic processes including gluconeogenesis and lipogenesis is partly attributable to activation of the AMP-activated …

 
 
 
 
 
 

A potential prognostic long non-coding RNA signature to predict metastasis-free survival of breast cancer patients

 
 

Jie Sun, Xihai Chen, Zhenzhen Wang et al.

 
 

Long non-coding RNAs (lncRNAs) have been implicated in a variety of biological processes, and dysregulated lncRNAs have demonstrated potential roles as biomarkers and therapeutic …

 
 
 
 
 
 

IL-6 Inhibits Starvation-induced Autophagy via the STAT3/Bcl-2 Signaling Pathway

 
 

Beibei Qin, Zhuo Zhou, Jianqin He et al.

 
 

IL-6, a pleiotropic cytokine, has been investigated for its role in regulating autophagy. Yet, its mechanism of action remains unclear. Here, we show that IL-6 exerted …

 
 
 
 
 
 

miR-150 Regulates Differentiation and Cytolytic Effector Function in CD8+ T cells

 
 

Norah L. Smith, Erin M. Wissink, Andrew Grimson et al.

 
 

MicroRNAs regulate most mammalian genes, and they control numerous aspects of immune system development and function. Their precise roles in the CD8+ T cell response, however, …

 
 
 
 
 
 

Late Eocene white pines (Pinus subgenus Strobus) from southern China

 
 

Qingqing Xu, Wenjun Zhou, Tatiana M. Kodrul et al.

 
 

Fossil records indicate that the genus Pinus L. split into two subgenera by the Late Cretaceous, although subgenus Strobus (D. Don) Lemmon is less well documented than subgenus

 
 
 
 
 
 

Olfaction and topography, but not magnetic cues, control navigation in a pelagic seabird: displacements with shearwaters in the Mediterranean Sea

 
 

Enrica Pollonara, Paolo Luschi, Tim Guilford et al.

 
 

Pelagic seabirds wander the open oceans then return accurately to their habitual nest-sites. We investigated the effects of sensory manipulation on oceanic navigation in …

 
 
 
 
 
 

Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1

 
 

Qingsi Wu, Jia Nie, Yayi Gao et al.

 
 

T helper 17 (Th17) cells not only play critical roles in protecting against bacterial and fungal infections but are also involved in the pathogenesis of autoimmune diseases. The …

 
 
 
 
 
 

Individual honey bee (Apis cerana) foragers adjust their fuel load to match variability in forage reward

 
 

Ken Tan, Tanya Latty, Shihao Dong et al.

 
 

Animals may adjust their behavior according to their perception of risk. Here we show that free-flying honey bee (Apis cerana) foragers mitigate the risk of starvation in the …

 
 
 
 
 
 

Convergent evolution of marine mammals is associated with distinct substitutions in common genes

 
 

Xuming Zhou, Inge Seim, Vadim N. Gladyshev

 
 

Phenotypic convergence is thought to be driven by parallel substitutions coupled with natural selection at the sequence level. Multiple independent evolutionary transitions of …

 
 
 
 
 
 

Identifying robust communities and multi-community nodes by combining top-down and bottom-up approaches to clustering

 
 

Chris Gaiteri, Mingming Chen, Boleslaw Szymanski et al.

 
 

Biological functions are carried out by groups of interacting molecules, cells or tissues, known as communities. Membership in these communities may overlap when biological …

 
 
 
 
 
 

The comparative risk of developing postoperative complications in patients with distal radius fractures following different treatment modalities

 
 

Wen-Jun Qiu, Yi-Fan Li, Yun-Han Ji et al.

 
 

In this study, we performed a network meta-analysis to compare the outcomes of seven most common surgical procedures to fix DRF, including bridging external fixation, …

 
 
 
 
 
 

A novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathway

 
 

Lei Li, Aprell L. Carr, Lei Sun et al.

 
 

The human oncogene SCL/TAL1 interrupting locus (Stil) is highly conserved in vertebrate species. Here, we report new findings of Stil in the regulation of toxic susceptibility in …

 
 
 
 
 
 

Revisiting the reference genomes of human pathogenic Cryptosporidium species: reannotation of C. parvum Iowa and a new C. hominis reference

 
 

Juan P. Isaza, Ana Luz Galván, Victor Polanco et al.

 
 

Cryptosporidium parvum and C. hominis are the most relevant species of this genus for human health. Both cause a self-limiting diarrhea in immunocompetent individuals, but cause …

 
 
 
 
 
 

LKB1 Regulates Cerebellar Development by Controlling Sonic Hedgehog-mediated Granule Cell Precursor Proliferation and Granule Cell Migration

 
 

Yuqin Men, Aizhen Zhang, Haixiang Li et al.

 
 

The Liver Kinase B1 (LKB1) gene plays crucial roles in cell differentiation, proliferation and the establishment of cell polarity. We created LKB1 conditional knockout mice (LKB1

 
 
 
 
 
 

Molecular Characterization of Growth Hormone-producing Tumors in the GC Rat Model of Acromegaly

 
 

Juan F. Martín-Rodríguez, Jose L. Muñoz-Bravo, Alejandro Ibañez-Costa et al.

 
 

Acromegaly is a disorder resulting from excessive production of growth hormone (GH) and consequent increase of insulin-like growth factor 1 (IGF-I), most frequently caused by …

 
 
 
 
 
 

The role of H4 flagella in Escherichia coli ST131 virulence

 
 

Asha Kakkanat, Makrina Totsika, Kolja Schaale et al.

 
 

Escherichia coli sequence type 131 (ST131) is a globally dominant multidrug resistant clone associated with urinary tract and bloodstream infections. Most ST131 strains exhibit …

 
 
 
 
 
 

The genetic regulatory network centered on Pto-Wuschela and its targets involved in wood formation revealed by association studies

 
 

Xiaohui Yang, Zunzheng Wei, Qingzhang Du et al.

 
 

Transcription factors (TFs) regulate gene expression and can strongly affect phenotypes. However, few studies have examined TF variants and TF interactions with their targets in …

 
 
 
 
 
 

Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature

 
 

Tsz Kin Ng, Jasmine S. Y. Yung, Kwong Wai Choy et al.

 
 

Retinal diseases are the leading causes of irreversible visual impairment and blindness in the developed countries. Human retina has limited regenerative power to replace cell …

 
 
 
 
 
 

Tea polyphenols as an antivirulence compound Disrupt Quorum-Sensing Regulated Pathogenicity of Pseudomonas aeruginosa

 
 

Honging Yin, Yifeng Deng, Huafu Wang et al.

 
 

Green tea, a water extract of non-fermented leaves of Camellia sinensis L., is one of the nonalcoholic beverages in China. It is becoming increasingly popular worldwide, because …

 
 
 
 
 
 

An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer

 
 

Yu-Ling Tai, Pei-Yu Chu, I-Rue Lai et al.

 
 

β4 integrin and focal adhesion kinase (FAK) are often associated with a poor prognosis in cancer patients, and their signaling events have recently been linked to malignant …

 
 
 
 
 
 

Excess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia

 
 

Tongshuai Zhang, Shaohong Fang, Cong Wan et al.

 
 

High salt diet (HSD) is one of the most important risk factors that contribute to many vascular diseases including ischemic stroke. One proposed mechanism underlying the …

 
 
 
 
 
 

Mitochondria-related miR-141-3p contributes to mitochondrial dysfunction in HFD-induced obesity by inhibiting PTEN

 
 

Juan Ji, Yufeng Qin, Jing Ren et al.

 
 

Mitochondria-related microRNAs (miRNAs) have recently emerged as key regulators of cell metabolism and can modulate mitochondrial fusion and division. In order to investigate the …

 
 
 
 
 
 

Ratiometric and colorimetric near-infrared sensors for multi-channel detection of cyanide ion and their application to measure β-glucosidase

 
 

Panfei Xing, Yongqian Xu, Hongjuan Li et al.

 
 

A near-infrared sensor for cyanide ion (CN) was developed via internal charge transfer (ICT). This sensor can selectively detect CN either through dual-ratiometric fluorescence …

 
 
 
 
 
 

SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α

 
 

Qilin Ao, Wenjing Su, Shuang Guo et al.

 
 

Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific …

 
 
 
 
 
 

Dual ligand/receptor interactions activate urothelial defenses against uropathogenic E. coli

 
 

Yan Liu, Sylvie Mémet, Ricardo Saban et al.

 
 

During urinary tract infection (UTI), the second most common bacterial infection, dynamic interactions take place between uropathogenic E. coli (UPEC) and host urothelial cells. …

 
 
 
 
 
 

Role of genetic mutations in folate-related enzyme genes on Male Infertility

 
 

Kang Liu, Ruizhe Zhao, Min Shen et al.

 
 

Several studies showed that the genetic mutations in the folate-related enzyme genes might be associated with male infertility; however, the results were still inconsistent. We …

 
 
 
 
 
 

Microbial immigration across the Mediterranean via airborne dust

 
 

Riccardo Rosselli, Maura Fiamma, Massimo Deligios et al.

 
 

Dust particles lifting and discharge from Africa to Europe is a recurring phenomenon linked to air circulation conditions. The possibility that microorganisms are conveyed across …

 
 
 
 
 
 

Mechanisms underlying the activity-dependent regulation of locomotor network performance by the Na+ pump

 
 

Hong-Yan Zhang, Laurence Picton, Wen-Chang Li et al.

 
 

Activity-dependent modification of neural network output usually results from changes in neurotransmitter release and/or membrane conductance. In Xenopus frog tadpoles, spinal …

 
 
 
 
 
 

Multiple exaggerated weapon morphs: a novel form of male polymorphism in harvestmen

 
 

Christina J. Painting, Anna F. Probert, Daniel J. Townsend et al.

 
 

Alternative reproductive tactics in animals are commonly associated with distinct male phenotypes resulting in polymorphism of sexually selected weapons such as horns and spines. …

 
 
 
 
 
 

Dense sampling reveals behavioral oscillations in rapid visual categorization

 
 

Jan Drewes, Weina Zhu, Andreas Wutz et al.

 
 

Perceptual systems must create discrete objects and events out of a continuous flow of sensory information. Previous studies have demonstrated oscillatory effects in the …

 
 
 
 
 
 

Lignosus rhinocerotis (Cooke) Ryvarden mimics the neuritogenic activity of nerve growth factor via MEK/ERK1/2 signaling pathway in PC-12 cells

 
 

Syntyche Ling-Sing Seow, Lee-Fang Eik, Murali Naidu et al.

 
 

The traditional application of the sclerotium of Lignosus rhinocerotis (tiger’s milk mushroom) by the indigenous folks as tonic and remedy to treat a variety of ailments has been …

 
 
 
 
 
 

Mycobacterium tuberculosis Inhibits RAB7 Recruitment to Selectively Modulate Autophagy Flux in Macrophages

 
 

Pallavi Chandra, Swapnil Ghanwat, Sumit Kumar Matta et al.

 
 

Here we report a novel regulatory mechanism for autophagy-mediated degradation of Mycobacterium tuberculosis (Mtb) and specific strategy exploited by the virulent Mtb to evade …

 
 
 
 
 
 

Corrigendum: Plasticity of Listeriolysin O Pores and its Regulation by pH and Unique Histidine

 
 

Marjetka Podobnik, Marta Marchioretto, Manuela Zanetti et al.

 
 

 
 
 
 
 
 

ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6

 
 

Ming-Tai Chen, Lei Dong, Xin-Hua Zhang et al.

 
 

RNA binding proteins (RBPs)-mediated post-transcriptional control has been implicated in influencing various aspects of RNA metabolism and playing important roles in mammalian …

 
 
 
 
 
 

The role of residence time in diagnostic models of global carbon storage capacity: model decomposition based on a traceable scheme

 
 

Chen Yizhao, Xia Jianyang, Sun Zhengguo et al.

 
 

As a key factor that determines carbon storage capacity, residence time (τE) is not well constrained in terrestrial biosphere models. This factor is recognized as an important …

 
 
 
 
 
 

Simultaneous effective carbon and nitrogen removals and phosphorus recovery in an intermittently aerated membrane bioreactor integrated system

 
 

Yun-Kun Wang, Xin-Rong Pan, Yi-Kun Geng et al.

 
 

Recovering nutrients, especially phosphate resource, from wastewater have attracted increasing interest recently. Herein, an intermittently aerated membrane bioreactor (MBR) with …

 
 
 
 
 
 

A High-content screen identifies compounds promoting the neuronal differentiation and the midbrain dopamine neuron specification of human neural progenitor cells

 
 

Ji heon Rhim, Xiangjian Luo, Xiaoyun Xu et al.

 
 

Small molecule compounds promoting the neuronal differentiation of stem/progenitor cells are of pivotal importance to regenerative medicine. We carried out a high-content screen …

 
 
 
 
 
 

Rapid identification of haloarchaea and methanoarchaea using the matrix assisted laser desorption/ionization time-of-flight mass spectrometry

 
 

Chao-Jen Shih, Sheng-Chung Chen, Chieh-Yin Weng et al.

 
 

The aim of this study was to classify certain environmental haloarchaea and methanoarchaea using matrix assisted laser desorption/ionization time-of-flight mass spectrometry …

 
 
 
 
 
 

Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery

 
 

Anupam Pradhan, Geoffrey H. Siwo, Naresh Singh et al.

 
 

The spread of Plasmodium falciparum multidrug resistance highlights the urgency to discover new targets and chemical scaffolds. Unfortunately, lack of experimentally validated …

 
 
 
 
 
 

A comparative genomics and reductive dehalogenase gene transcription study of two chloroethene-respiring bacteria, Dehalococcoides mccartyi strains MB and 11a

 
 

Adrian Low, Zhiyong Shen, Dan Cheng et al.

 
 

Genomes of two trichloroethene (TCE)-respiring Dehalococcoides (Dhc) mccartyi, strains MB and 11a, were sequenced to identify reductive dehalogenases (RDase) responsible for …

 
 
 
 
 
 

A high risk of osteosarcoma in individuals who are homozygous for the p.D104N in endostatin

 
 

Wen-Zhi Bi, Dian-Wei Li, Song Luo et al.

 
 

The D104N polymorphism (p.D104N) in endostatin has been previously identified in many types of cancer, and this polymorphism is believed to be a phenotypic modulator in some …

 
 
 
 
 
 

Synthetic Tet-inducible artificial microRNAs targeting β-catenin or HIF-1α inhibit malignant phenotypes of bladder cancer cells T24 and 5637

 
 

Yonghao Zhan, Yuchen Liu, Junhao Lin et al.

 
 

Ribonucleic acid interference (RNAi) based on microRNA (miRNA) may provide efficient and safe therapeutic opportunities. However, natural microRNAs can not easily be regulated …

 
 
 
 
 
 

Enhanced response inhibition in experienced fencers

 
 

Dandan Zhang, Haiyan Ding, Xiaochun Wang et al.

 
 

The inhibition of a prepotent response is an essential executive function which enables us to suppress inappropriate actions in a given context. Individuals with fencing …

 
 
 
 
 
 

Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound

 
 

Patrick Merle, Marine Gueugneau, Marie-Paule Teulade-Fichou et al.

 
 

Telomeres are nucleoprotein structures at the end of chromosomes which stabilize and protect them from nucleotidic degradation and end-to-end fusions. The G-rich telomeric …

 
 
 
 
 
 

Evolutionarily Conserved Sequence Features Regulate the Formation of the FG Network at the Center of the Nuclear Pore Complex

 
 

M. Peyro, M. Soheilypour, B.L. Lee et al.

 
 

The nuclear pore complex (NPC) is the portal for bidirectional transportation of cargos between the nucleus and the cytoplasm. While most of the structural elements of the NPC, …

 
 
 
 
 
 

The effect of short-chain fatty acids on human monocyte-derived dendritic cells

 
 

Claudia Nastasi, Marco Candela, Charlotte Menné Bonefeld et al.

 
 

The gut microbiota is essential for human health and plays an important role in the pathogenesis of several diseases. Short-chain fatty acids (SCFA), such as acetate, butyrate …

 
 
 
 
 
 

Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia

 
 

Thomas Palm, Silvia Bolognin, Johannes Meiser et al.

 
 

Induced pluripotent stem cell bear the potential to differentiate into any desired cell type and hold large promise for disease-in-a-dish cell-modeling approaches. With the …

 
 
 
 
 
 

Combination of acamprosate and baclofen as a promising therapeutic approach for Parkinson’s disease

 
 

Rodolphe Hajj, Aude Milet, Damien Toulorge et al.

 
 

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic nigrostriatal neurons but which involves the loss of additional …

 
 
 
 
 
 

Increased costs reduce reciprocal helping behaviour of humans in a virtual evacuation experiment

 
 

Nikolai W. F. Bode, Jordan Miller, Rick O’Gorman et al.

 
 

Altruistic behaviour is widespread and highly developed in humans and can also be found in some animal species. It has been suggested that altruistic tendencies can depend on …

 
 
 
 
 
 

Brain size regulations by cbp haploinsufficiency evaluated by in-vivo MRI based volumetry

 
 

Juan C. Ateca-Cabarga, Alejandro Cosa, Vicente Pallarés et al.

 
 

The Rubinstein-Taybi Syndrome (RSTS) is a congenital disease that affects brain development causing severe cognitive deficits. In most cases the disease is associated with …

 
 
 
 
 
 

De novo protein conformational sampling using a probabilistic graphical model

 
 

Debswapna Bhattacharya, Jianlin Cheng

 
 

Efficient exploration of protein conformational space remains challenging especially for large proteins when assembling discretized structural fragments extracted from a protein …

 
 
 
 
 
 

A method for estimating spikelet number per panicle: Integrating image analysis and a 5-point calibration model

 
 

Sanqin Zhao, Jiabing Gu, Youyong Zhao et al.

 
 

Spikelet number per panicle (SNPP) is one of the most important yield components used to estimate rice yields. The use of high-throughput quantitative image analysis methods for …

 
 
 
 
 
 

Targeted, noninvasive blockade of cortical neuronal activity

 
 

Nathan McDannold, Yongzhi Zhang, Chanikarn Power et al.

 
 

Here we describe a novel method to noninvasively modulate targeted brain areas through the temporary disruption of the blood-brain barrier (BBB) via focused ultrasound, enabling …

 
 
 
 
 
 

Effect of Regular Exercise on Inflammation Induced by Drug-resistant Staphylococcus aureus 3089 in ICR mice

 
 

Jong-Kook Lee, Tudor Luchian, Yoonkyung Park

 
 

Obesity is often associated with irregular dietary habits and reduced physical activity. Regular exercise induces a metabolic response that includes increased expression of …

 
 
 
 
 
 

Neutralization of Japanese Encephalitis Virus by heme-induced broadly reactive human monoclonal antibody

 
 

Nimesh Gupta, Mélissanne de Wispelaere, Maxime Lecerf et al.

 
 

Geographical expansion and re-emerging new genotypes of the Japanese encephalitis virus (JEV) require the development of novel therapeutic approaches. Here, we studied a …

 
 
 
 
 
 

Fine-tuning of synaptic upscaling at excitatory synapses by endocannabinoid signaling is mediated via the CB1 receptor

 
 

Yunping Song, Jian Zhang, Chu Chen

 
 

The endocannabinoid 2-arachidonoylglycerol (2-AG) functions as a retrograde signaling molecule mediating synaptic transmission and plasticity at both inhibitory and excitatory …

 
 
 
 
 
 

Pregnancy diabetes: A comparison of diagnostic protocols based on point-of-care, routine and optimized laboratory conditions

 
 

Sjoerd A. A. van den Berg, Monique J. M. de Groot, Lorenzo P. W. Salden et al.

 
 

In vitro glycolysis poses a problem during diabetes screening, especially in remote laboratories. Point-of-care analysis (POC) may provide an alternative. We compared POC, …

 
 
 
 
 
 

Targeting extra-oral bitter taste receptors modulates gastrointestinal motility with effects on satiation

 
 

Bert Avau, Alessandra Rotondo, Theo Thijs et al.

 
 

Bitter taste receptors (TAS2Rs) are present in extra-oral tissues, including gut endocrine cells. This study explored the presence and mechanism of action of TAS2R agonists on …

 
 
 
 
 
 

(Z)3,4,5,4′-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level

 
 

Xing-Xing Fan, Xiao-Jun Yao, Su Wei Xu et al.

 
 

Calcium is a second messenger which is required for regulation of many cellular processes. However, excessive elevation or prolonged activation of calcium signaling would lead to …

 
 
 
 
 
 

Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity

 
 

Frederic Boal, Jessica Roumegoux, Chiara Alfarano et al.

 
 

The increasing incidence of obesity accentuates the importance of identifying mechanisms and optimal therapeutic strategies for patients with heart failure (HF) in relation to …

 
 
 
 
 
 

Orexin/Hypocretin-1 Receptor Antagonism Selectively Reduces Cue-Induced Feeding in Sated Rats and Recruits Medial Prefrontal Cortex and Thalamus

 
 

Sindy Cole, Heather S. Mayer, Gorica D. Petrovich

 
 

The orexin/hypocretin system is important for reward-seeking behaviors, however less is known about its function in non-homeostatic feeding. Environmental influences, …

 
 
 
 
 
 

Homogeneous fluorescent specific PCR for the authentication of medicinal snakes using cationic conjugated polymers

 
 

Chao Jiang, Yuan Yuan, Libing Liu et al.

 
 

A label-free, homogenous and sensitive one-step method for the molecular authentication of medicinal snakes has been developed by combining a rapid PCR technique with …

 
 
 
 
 
 

Insights into immune responses in oral cancer through proteomic analysis of saliva and salivary extracellular vesicles

 
 

Flavia V. Winck, Ana Carolina Prado Ribeiro, Romênia Ramos Domingues et al.

 
 

The development and progression of oral cavity squamous cell carcinoma (OSCC) involves complex cellular mechanisms that contribute to the low five-year survival rate of …

 
 
 
 
 
 

Biomarker- and similarity coefficient-based approaches to bacterial mixture characterization using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS)

 
 

Lin Zhang, Sonja Smart, Todd R Sandrin

 
 

MALDI-TOF MS profiling has been shown to be a rapid and reliable method to characterize pure cultures of bacteria. Currently, there is keen interest in using this technique to …

 
 
 
 
 
 

Genotype-dependent lifespan effects in peptone deprived Caenorhabditis elegans

 
 

Jana J. Stastna, L. Basten Snoek, Jan E. Kammenga et al.

 
 

Dietary restriction appears to act as a general non-genetic mechanism that can robustly prolong lifespan. There have however been reports in many systems of cases where …

 
 
 
 
 
 

Enduring deficits in memory and neuronal pathology after blast-induced traumatic brain injury

 
 

Venkata Siva Sai Sujith Sajja, W. Brad Hubbard, Christina S. Hall et al.

 
 

Few preclinical studies have assessed the long-term neuropathology and behavioral deficits after sustaining blast-induced neurotrauma (BINT). Previous studies have shown …

 
 
 
 
 
 

Improving chemotherapeutic efficiency in acute myeloid leukemia treatments by chemically synthesized peptide interfering with CXCR4/CXCL12 axis

 
 

Xiaojin Li, Hua Guo, Hongyang Duan et al.

 
 

Bone marrow stroma can protect acute myeloid leukemia (AML) cells against chemotherapeutic agents and provide anti-apoptosis and chemoresistance signals through secreting …

 
 
 
 
 
 

Specific N-glycans of Hepatocellular Carcinoma Cell Surface and the Abnormal Increase of Core-α-1, 6-fucosylated Triantennary Glycan via N-acetylglucosaminyltransferases-IVa Regulation

 
 

Huan Nie, Xia Liu, Yubao Zhang et al.

 
 

Glycosylation alterations of cell surface proteins are often observed during the progression of malignancies. The specific cell surface N-glycans were profiled in hepatocellular …

 
 
 
 
 
 

2A self-cleaving peptide-based multi-gene expression system in the silkworm Bombyx mori

 
 

Yuancheng Wang, Feng Wang, Riyuan Wang et al.

 
 

Fundamental and applied studies of silkworms have entered the functional genomics era. Here, we report a multi-gene expression system (MGES) based on 2A self-cleaving peptide …

 
 
 
 
 
 

Substrates of the ASB2α E3 ubiquitin ligase in dendritic cells

 
 

Camille A. Spinner, Sandrine Uttenweiler-Joseph, Arnaud Metais et al.

 
 

Conventional dendritic cells (cDCs) comprise distinct populations with specialized immune functions that are mediators of innate and adaptive immune responses. Transcriptomic and …

 
 
 
 
 
 

Genetic evidence of a recent Tibetan ancestry to Sherpas in the Himalayan region

 
 

Sushil Bhandari, Xiaoming Zhang, Chaoying Cui et al.

 
 

Sherpas living around the Himalayas are renowned as high-altitude mountain climbers but when and where the Sherpa people originated from remains contentious. In this study, we …

 
 
 
 
 
 

A striking reduction of simple loudness adaptation in autism

 
 

Rebecca P. Lawson, Jessica Aylward, Sarah White et al.

 
 

Reports of sensory disturbance, such as loudness sensitivity or sound intolerance, are ubiquitous in Autism Spectrum Disorder (ASD) but a mechanistic explanation for these …

 
 
 
 
 
 

The functional gene composition and metabolic potential of coral-associated microbial communities

 
 

Yanying Zhang, Juan Ling, Qingsong Yang et al.

 
 

The phylogenetic diversity of coral-associated microbes has been extensively examined, but some contention remains regarding whether coral-associated microbial communities are …

 
 
 
 
 
 

Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma

 
 

Takumi Kumai, Takayuki Ohkuri, Toshihiro Nagato et al.

 
 

HER-3 expression has been reported to act as an important oncoprotein in head and neck squamous cell carcinoma. This protein is known to control tumor proliferation and …

 
 
 
 
 
 

Comprehensive analysis of transcriptome and metabolome analysis in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma

 
 

Yoshiki Murakami, Shoji Kubo, Akihiro Tamori et al.

 
 

Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are liver originated malignant tumors. Of the two, ICC has the worse prognosis because it has no reliable …

 
 
 
 
 
 

Molecular changes in the medial prefrontal cortex and nucleus accumbens are associated with blocking the behavioral sensitization to cocaine

 
 

Yi Zhang, Xiongzhao Zhu, Can Huang et al.

 
 

Previous studies have demonstrated that cocaine-induced behavioral sensitization is associated with persistent functional and structural alterations in the medial prefrontal …

 
 
 
 
 
 

Slc15a1 is involved in the transport of synthetic F5-peptide into the seminiferous epithelium in adult rat testes

 
 

Linlin Su, Yufei Zhang, Yan C. Cheng et al.

 
 

Spermiation and BTB restructuring, two critical cellular events that occur across seminiferous epithelium in mammalian testis during spermatogenesis, are tightly coordinated by …

 
 
 
 
 
 

Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis

 
 

De-Ke Jiang, Xiao-Pin Ma, Xiaopan Wu et al.

 
 

Recent genome-wide associated studies (GWASs) have revealed several common loci associated with the risk of hepatitis B virus (HBV)- or hepatitis C virus (HCV)-related …

 
 
 
 
 
 

Substrate recognition and catalysis by LytB, a pneumococcal peptidoglycan hydrolase involved in virulence

 
 

Palma Rico-Lastres, Roberto Díez-Martínez, Manuel Iglesias-Bexiga et al.

 
 

Streptococcus pneumoniae is a major cause of life-threatening diseases worldwide. Here we provide an in-depth functional characterization of LytB, the peptidoglycan hydrolase …

 
 
 
 
 
 

Modification of sperm morphology during long-term sperm storage in the reproductive tract of the Chinese soft-shelled turtle, Pelodiscus sinensis

 
 

Linli Zhang, Ping Yang, Xunguang Bian et al.

 
 

Sperm storage in vivo extends the time window for fertilisation in several animal species, from a few days to several years. The underlying storage mechanisms, however, are …

 
 
 
 
 
 

Folic acid protects against arsenic-mediated embryo toxicity by up-regulating the expression of Dvr1

 
 

Yan Ma, Chen Zhang, Xiao-Bo Gao et al.

 
 

As a nutritional factor, folic acid can prevent cardiac and neural defects during embryo development. Our previous study showed that arsenic impairs embryo development by …

 
 
 
 
 
 

Complex patterns of signalling to convey different social goals of sex in bonobos, Pan paniscus

 
 

Emilie Genty, Christof Neumann, Klaus Zuberbühler

 
 

Sexual behaviour in bonobos (Pan paniscus) functions beyond mere reproduction to mediate social interactions and relationships. In this study, we assessed the signalling …

 
 
 
 
 
 

Long-term moderate treadmill exercise promotes stress-coping strategies in male and female rats

 
 

Jaume F. Lalanza, Sandra Sanchez-Roige, Igor Cigarroa et al.

 
 

Recent evidence has revealed the impact of exercise in alleviating anxiety and mood disorders; however, the exercise protocol that exerts such benefit is far from known. The …

 
 
 
 
 
 

Preliminary Characterization of a Leptin Receptor Knockout Rat Created by CRISPR/Cas9 System

 
 

Dan Bao, Yuanwu Ma, Xu Zhang et al.

 
 

Leptin receptor, which is encoded by the diabetes (db) gene and is highly expressed in the choroid plexus, regulatesenergy homeostasis, the balance between food intake and energy …

 
 
 
 
 
 

Life history and dynamics of a platypus (Ornithorhynchus anatinus) population: four decades of mark-recapture surveys

 
 

Gilad Bino, Tom R. Grant, Richard T. Kingsford

 
 

Knowledge of the life-history and population dynamics of Australia’s iconic and evolutionarily distinct platypus (Ornithorhynchus anatinus) remains poor. We marked-recaptured 812 …

 
 
 
 
 
 

Venous Endothelial Marker COUP-TFII Regulates the Distinct Pathologic Potentials of Adult Arteries and Veins

 
 

Xiaofeng Cui, Yao Wei Lu, Vivian Lee et al.

 
 

Arteries and veins have very different susceptibility to certain vascular diseases such as atherosclerosis and vascular calcification. The molecular mechanisms of these …

 
 
 
 
 
 

Integrated Genome-wide association and hypothalamus eQTL studies indicate a link between the circadian rhythm-related gene PER1 and coping behavior

 
 

Siriluck Ponsuksili, Manuela Zebunke, Eduard Murani et al.

 
 

Animal personality and coping styles are basic concepts for evaluating animal welfare. Struggling response of piglets in so-called backtests early in life reflects their coping …

 
 
 
 
 
 

Barnyard grasses were processed with rice around 10000 years ago

 
 

Xiaoyan Yang, Dorian Q Fuller, Xiujia Huan et al.

 
 

Rice (Oryza sativa) is regarded as the only grass that was selected for cultivation and eventual domestication in the Yangtze basin of China. Although both macro-fossils and …

 
 
 
 
 
 

Involvement of opsins in mammalian sperm thermotaxis

 
 

Serafín Pérez-Cerezales, Sergii Boryshpolets, Oshri Afanzar et al.

 
 

A unique characteristic of mammalian sperm thermotaxis is extreme temperature sensitivity, manifested by the capacity of spermatozoa to respond to temperature changes of <…

 
 
 
 
 
 

Structural Characterization of a Newly Identified Component of α-Carboxysomes: The AAA+ Domain Protein CsoCbbQ

 
 

Markus Sutter, Evan W. Roberts, Raul C. Gonzalez et al.

 
 

Carboxysomes are bacterial microcompartments that enhance carbon fixation by concentrating ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and its substrate CO2 within …

 
 
 
 
 
 

The C-terminal Domain Supports a Novel Function for CETPI as a New Plasma Lipopolysaccharide-Binding Protein

 
 

Victor García-González, Nadia Gutiérrez-Quintanar, Jaime Mas-Oliva

 
 

Described by our group a few years ago, the cholesteryl-ester transfer protein isoform (CETPI), exclusively expressed in the small intestine and present in human plasma, lacked a …

 
 
 
 
 
 

N-acetylcysteine inhibits in vivo oxidation of native low-density lipoprotein

 
 

Yuqi Cui, Chandrakala A. Narasimhulu, Lingjuan Liu et al.

 
 

Low-density lipoprotein (LDL) is non-atherogenic, while oxidized LDL (ox-LDL) is critical to atherosclerosis. N-acetylcysteine (NAC) has anti-atherosclerotic effect with largely …

 
 
 
 
 
 

Screening and Molecular Analysis of Single Circulating Tumor Cells Using Micromagnet Array

 
 

Yu-Yen Huang, Peng Chen, Chun-Hsien Wu et al.

 
 

Immunomagnetic assay has been developed to detect rare circulating tumor cells (CTCs), which shows clinical significance in cancer diagnosis and prognosis. The generation and …

 
 
 
 
 
 

Quantification of NS1 dengue biomarker in serum via optomagnetic nanocluster detection

 
 

Paula Antunes, Daniel Watterson, Mattias Parmvi et al.

 
 

Dengue is a tropical vector-borne disease without cure or vaccine that progressively spreads into regions with temperate climates. Diagnostic tools amenable to resource-limited …

 
 
 
 
 
 

A transgenic embryonic sexing system for the Australian sheep blow fly Lucilia cuprina

 
 

Ying Yan, Maxwell J. Scott

 
 

Genetic approaches, including the sterile insect technique (SIT), have previously been considered for control of the Australian sheep blow fly Lucilia cuprina, a major pest of …

 
 
 
 
 
 

Age-associated changes in rich-club organisation in autistic and neurotypical human brains

 
 

Takamitsu Watanabe, Geraint Rees

 
 

Macroscopic structural networks in the human brain have a rich-club architecture comprising both highly inter-connected central regions and sparsely connected peripheral regions. …

 
 
 
 
 
 

Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition

 
 

Asfar S. Azmi, Irfana Muqbil, Jack Wu et al.

 
 

Here we demonstrate for the first time that targeted inhibition of nuclear exporter protein exportin 1 (XPO1) also known as chromosome maintenance region 1 (CRM1) by Selective …

 
 
 
 
 
 

Inhibition of actin polymerization in the NAc shell inhibits morphine-induced CPP by disrupting its reconsolidation

 
 

Gongying Li, Yanmei Wang, Min Yan et al.

 
 

Drug-associated contextual cues contribute to drug craving and relapse after abstinence, which is a major challenge to drug addiction treatment. Previous studies showed that …

 
 
 
 
 
 

Lactobacillus rhamnosus GG Lysate Increases Re-Epithelialization of Keratinocyte Scratch Assays by Promoting Migration

 
 

Walaa Mohammedsaeed, Sheena Cruickshank, Andrew J. McBain et al.

 
 

A limited number of studies have investigated the potential of probiotics to promote wound healing in the digestive tract. The aim of the current investigation was to determine …

 
 
 
 
 
 

Mutual and asynchronous anticipation and action in sports as globally competitive and locally coordinative dynamics

 
 

Keisuke Fujii, Tadao Isaka, Motoki Kouzaki et al.

 
 

Humans interact by changing their actions, perceiving other’s actions and executing solutions in conflicting situations. Using oscillator models, nonlinear dynamics have been …

 
 
 
 
 
 

Bioaggregate of photo-fermentative bacteria for enhancing continuous hydrogen production in a sequencing batch photobioreactor

 
 

Guo-Jun Xie, Bing-Feng Liu, Rui-Qing Wang et al.

 
 

Hydrogen recovery through solar-driven biomass conversion by photo-fermentative bacteria (PFB) has been regarded as a promising way for sustainable energy production. However, a …

 
 
 
 
 
 

Emergence of Hemagglutinin Mutations During the Course of Influenza Infection

 
 

Anna Cushing, Amanda Kamali, Mark Winters et al.

 
 

Influenza remains a significant cause of disease mortality. The ongoing threat of influenza infection is partly attributable to the emergence of new mutations in the influenza …

 
 
 
 
 
 

CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs

 
 

Yonggang Zhang, Chaoran Yin, Ting Zhang et al.

 
 

Current antiretroviral therapy does not eliminate the integrated and transcriptionally silent HIV-1 provirus in latently infected cells. Recently, a “shock and kill” strategy has …

 
 
 
 
 
 

Systems biology-guided identification of synthetic lethal gene pairs and its potential use to discover antibiotic combinations

 
 

Ramy K. Aziz, Jonathan M. Monk, Robert M. Lewis et al.

 
 

Mathematical models of metabolism from bacterial systems biology have proven their utility across multiple fields, for example metabolic engineering, growth phenotype simulation, …

 
 
 
 
 
 

Adaptation of the autotrophic acetogen Sporomusa ovata to methanol accelerates the conversion of CO2 to organic products

 
 

Pier-Luc Tremblay, Daniel Höglund, Anna Koza et al.

 
 

Acetogens are efficient microbial catalysts for bioprocesses converting C1 compounds into organic products. Here, an adaptive laboratory evolution approach was implemented to …

 
 
 
 
 
 

Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure

 
 

Chengli Ding, Zhifei Wu, Lei Huang et al.

 
 

The inner mitochondrial membrane (IMM) invaginates to form cristae and the maintenance of cristae depends on the mitochondrial contact site (MICOS) complex. Mitofilin and CHCHD6, …

 
 
 
 
 
 

Comparative genomics and experimental evolution of Escherichia coli BL21(DE3) strains reveal the landscape of toxicity escape from membrane protein overproduction

 
 

Soon-Kyeong Kwon, Seong Keun Kim, Dae-Hee Lee et al.

 
 

Achieving sufficient yields of proteins in their functional form represents the first bottleneck in contemporary bioscience and biotechnology. To accomplish successful …

 
 
 
 
 
 

Coevolutionary dynamics between tribe Cercopithecini tetherins and their lentiviruses

 
 

Junko S. Takeuchi, Fengrong Ren, Rokusuke Yoshikawa et al.

 
 

Human immunodeficiency virus, a primate lentivirus (PLV), causes AIDS in humans, whereas most PLVs are less or not pathogenic in monkeys. These notions suggest that the …

 
 
 
 
 
 

Abnormalities in synaptic dynamics during development in a mouse model of spinocerebellar ataxia type 1

 
 

Yusuke Hatanaka, Kei Watase, Keiji Wada et al.

 
 

Late-onset neurodegenerative diseases are characterized by neurological symptoms and progressive neuronal death. Accumulating evidence suggests that neuronal dysfunction, rather …

 
 
 
 
 
 

Differential regulation of receptivity in two uterine horns of a recipient mouse following asynchronous embryo transfer

 
 

Shi-Jie Li, Tong-Song Wang, Fu-Niu Qin et al.

 
 

Receptivity is a limited time in which uterine endometrium can establish a successful dialogue with blastocyst. This study was to investigate the effect of asynchronous embryo …

 
 
 
 
 
 

Stroma-associated master regulators of molecular subtypes predict patient prognosis in ovarian cancer

 
 

Shengzhe Zhang, Ying Jing, Meiying Zhang et al.

 
 

High-grade serous ovarian carcinoma (HGS-OvCa) has the lowest survival rate among all gynecologic cancers and is hallmarked by a high degree of heterogeneity. The Cancer Genome …

 
 
 
 
 
 

Compartmentalized microchannel array for high-throughput analysis of single cell polarized growth and dynamics

 
 

Tao Geng, Erin L. Bredeweg, Craig J. Szymanski et al.

 
 

Interrogating polarized growth is technologically challenging due to extensive cellular branching and uncontrollable environmental conditions in conventional assays. Here we …

 
 
 
 
 
 

Human corneal stromal stem cells support limbal epithelial cells cultured on RAFT tissue equivalents

 
 

Alvena K Kureshi, Marc Dziasko, James L Funderburgh et al.

 
 

Human limbal epithelial cells (HLE) and corneal stromal stem cells (CSSC) reside in close proximity in vivo in the corneal limbal stem cell niche. However, HLE are typically …

 
 
 
 
 
 

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

 
 

Andre L. Samson, Lining Ju, Hyun Ah Kim et al.

 
 

The Open Field (OF) test is one of the most commonly used assays for assessing exploratory behaviour and generalised locomotor activity in rodents. Nevertheless, the vast …

 
 
 
 
 
 

Human cooperation in groups: variation begets variation

 
 

Pieter van den Berg, Lucas Molleman, Jaakko Junikka et al.

 
 

Many experiments on human cooperation have revealed that individuals differ systematically in their tendency to cooperate with others. It has also been shown that individuals …

 
 
 
 
 
 

Disadvantageous associations: Reversible spatial cueing effects in a discrimination task

 
 

Daniele Nico, Elena Daprati

 
 

Current theories describe learning in terms of cognitive or associative mechanisms. To assess whether cognitive mechanisms interact with automaticity of associative processes we …

 
 
 
 
 
 

Targeted DNA Sequencing Detects Mutations Related to Susceptibility among Familial Non-medullary Thyroid Cancer

 
 

Yang Yu, Li Dong, Dapeng Li et al.

 
 

Some studies have demonstrated that familial non-medullary thyroid cancer (FNMTC) has a more aggressive clinical behavior compared to sporadic NMTC (SNMTC). However, FNMTC is …

 
 
 
 
 
 

Isolation of Rhp-PSP, a member of YER057c/YjgF/UK114 protein family with antiviral properties, from the photosynthetic bacterium Rhodopseudomonas palustris strain JSC-3b

 
 

Pin Su, Tuizi Feng, Xuguo Zhou et al.

 
 

Rhodopseudomonas palustris strain JSC-3b isolated from a water canal adjacent to a vegetable field produces a protein that was purified by bioactivity-guided fractionation based …

 
 
 
 
 
 

Designing overall stoichiometric conversions and intervening metabolic reactions

 
 

Anupam Chowdhury, Costas D. Maranas

 
 

Existing computational tools for de novo metabolic pathway assembly, either based on mixed integer linear programming techniques or graph-search applications, generally only find …

 
 
 
 
 
 

Identification and functional analysis of novel FZD4 mutations in Han Chinese with familial exudative vitreoretinopathy

 
 

Ping Fei, Xiong Zhu, Zhilin Jiang et al.

 
 

Familial exudative vitreoretinopathy (FEVR) is a hereditary eye disease characterized by defects in the development of retinal vessels. However, known genetic mutations can only …

 
 
 
 
 
 

Integrated analysis of microRNA and mRNA expression profiles in abdominal adipose tissues in chickens

 
 

H. Y. Huang, R. R. Liu, G. P. Zhao et al.

 
 

Excessive fat accretion is a crucial problem during broiler production. Abdominal fat weight (AbFW) and abdominal fat percentage (AbFP) are major phenotypic indices of fat …

 
 
 
 
 
 

CUG-BP1 regulates RyR1 ASI alternative splicing in skeletal muscle atrophy

 
 

Yinglong Tang, Huiwen Wang, Bin Wei et al.

 
 

RNA binding protein is identified as an important mediator of aberrant alternative splicing in muscle atrophy. The altered splicing of calcium channels, such as ryanodine …

 
 
 
 
 
 

Identification of Reliable Components in Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS): a Data-Driven Approach across Metabolic Processes

 
 

Hiromi Motegi, Yuuri Tsuboi, Ayako Saga et al.

 
 

There is an increasing need to use multivariate statistical methods for understanding biological functions, identifying the mechanisms of diseases, and exploring biomarkers. In …

 
 
 
 
 
 

Dnmts and Tet target memory-associated genes after appetitive olfactory training in honey bees

 
 

Stephanie D. Biergans, C. Giovanni Galizia, Judith Reinhard et al.

 
 

DNA methylation and demethylation are epigenetic mechanisms involved in memory formation. In honey bees DNA methyltransferase (Dnmt) function is necessary for long-term memory to …

 
 
 
 
 
 

Analysis of the TCP genes expressed in the inflorescence of the orchid Orchis italica

 
 

Sofia De Paolo, Luciano Gaudio, Serena Aceto

 
 

TCP proteins are plant-specific transcription factors involved in many different processes. Because of their involvement in a large number of developmental pathways, their roles …

 
 
 
 
 
 

Neuromuscular regulation in zebrafish by a large AAA+ ATPase/ubiquitin ligase, mysterin/RNF213

 
 

Yuri Kotani, Daisuke Morito, Satoru Yamazaki et al.

 
 

Mysterin (also known as RNF213) is a huge intracellular protein with two AAA+ ATPase modules and a RING finger ubiquitin ligase domain. Mysterin was originally isolated as a …

 
 
 
 
 
 

The Mycobacterium tuberculosis H37Ra gene MRA_1916 causes growth defects upon down-regulation

 
 

Kumar Sachin Singh, Sudheer Kumar Singh

 
 

D-amino acid oxidases play an important role in converting D-amino acids to their corresponding α-keto acids. MRA_1916 of Mycobacterium tuberculosis H37Ra (Mtb-Ra) is annotated …

 
 
 
 
 
 

IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance

 
 

Yi-Fan Lu, David M. Mauger, David B. Goldstein et al.

 
 

Polymorphisms near the interferon lambda 3 (IFNL3) gene strongly predict clearance of hepatitis C virus (HCV) infection. We analyzed a variant (rs4803217 G/T) located within the …

 
 
 
 
 
 

CD44 deficiency inhibits unloading-induced cortical bone loss through downregulation of osteoclast activity

 
 

Yuheng Li, Guohui Zhong, Weijia Sun et al.

 
 

The CD44 is cellular surface adhesion molecule that is involved in physiological processes such as hematopoiesis, lymphocyte homing and limb development. It plays an important …

 
 
 
 
 
 

Physiological Function of Rac Prophage During Biofilm Formation and Regulation of Rac Excision in Escherichia coli K-12

 
 

Xiaoxiao Liu, Yangmei Li, Yunxue Guo et al.

 
 

Rac or rac-like prophage harbors many genes with important physiological functions, while it remains excision-proficient in several bacterial strains including Escherichia coli,

 
 
 
 
 
 

Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer’s disease

 
 

Xue Wang, Haribalan Perumalsamy, Hyung Wook Kwon et al.

 
 

The human β-amyloid (Aβ) cleaving enzyme (BACE-1) is a target for Alzheimer’s disease (AD) treatments. This study was conducted to determine if acacetin extracted from the whole

 
 
 
 
 
 

High specific selectivity and Membrane-Active Mechanism of the synthetic centrosymmetric α-helical peptides with Gly-Gly pairs

 
 

Jiajun Wang, Shuli Chou, Lin Xu et al.

 
 

We used a template-assisted approach to develop synthetic antimicrobial peptides, which differ from naturally occurring antimicrobial peptides that can compromise host natural …

 
 
 
 
 
 

Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B

 
 

Satomi Mukai, Norikazu Yabuta, Kaori Yoshida et al.

 
 

Numerical aberration of the centrosome results in chromosome missegregation, eventually leading to chromosomal instability, a hallmark of human tumor malignancy. Large tumor …

 
 
 
 
 
 

Comparative genomic and transcriptional analyses of the carbohydrate-active enzymes and secretomes of phytopathogenic fungi reveal their significant roles during infection and development

 
 

Xueliang Lyu, Cuicui Shen, Yanping Fu et al.

 
 

Our comparative genomic analysis showed that the numbers of plant cell wall (PCW)- and fungal cell wall (FCW)-degradation-associated carbohydrate-active enzymes (CAZymes) in …

 
 
 
 
 
 

Glaucumolides A and B, Biscembranoids with New Structural Type from a Cultured Soft Coral Sarcophyton glaucum

 
 

Chiung-Yao Huang, Ping-Jyun Sung, Chokkalingam Uvarani et al.

 
 

Glaucumolides A (1) and B (2), novel biscembranes composed of an unprecedented α,β-unsaturated ε-lactone, along with the known metabolites ximaolide A (3) and isosarcophytonolide …

 
 
 
 
 
 

Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like “nightmares” in rats

 
 

Bin Yu, Su-Ying Cui, Xue-Qiong Zhang et al.

 
 

Posttraumatic nightmares are a core component of posttraumatic stress disorder (PTSD) and mechanistically linked to the development and maintenance of this disorder, but little …

 
 
 
 
 
 

No effect on pharmacokinetics of tamoxifen and 4-hydroxytamoxifen by multiple doses of red clover capsule in rats

 
 

Kanumuri Siva Rama Raju, Isha Taneja, Guru Raghavendra Valicherla et al.

 
 

Tamoxifen is used in clinical practice for breast cancer patients and to prevent osteoporosis. Red clover (Trifolium pratense) preparations are consumed worldwide as dietary …

 
 
 
 
 
 

A novel 2,5-diaminopyrimidine-based affinity probe for Bruton’s tyrosine kinase

 
 

Yingying Zuo, Yanxia Shi, Xitao Li et al.

 
 

As a critical regulator of the B-cell receptor signaling pathway, Bruton’s tyrosine kinase (Btk) has attracted intensive drug discovery efforts for treating B-cell lineage …

 
 
 
 
 
 

Highly sensitive image-derived indices of water-stressed plants using hyperspectral imaging in SWIR and histogram analysis

 
 

David M. Kim, Hairong Zhang, Haiying Zhou et al.

 
 

The optical signature of leaves is an important monitoring and predictive parameter for a variety of biotic and abiotic stresses, including drought. Such signatures derived from …

 
 
 
 
 
 

H2S, a novel gasotransmitter, involves in gastric accommodation

 
 

Ailin Xiao, Hongjuan Wang, Xin Lu et al.

 
 

H2S is produced mainly by two enzymes:cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE), using L-cysteine (L-Cys) as the substrate. In this study, we investigated …

 
 
 
 
 
 

Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer

 
 

Zheyu Niu, Mengyi Wang, Li Zhou et al.

 
 

Glucose-regulated protein 78 (GRP78) is a member of the heat-shock protein 70 family. We evaluated the expression of GRP78 using tissue microarray-based immunohistochemistry in …

 
 
 
 
 
 

Administration of defined microbiota is protective in a murine Salmonella infection model

 
 

Sarah-Lynn E. Martz, Julie A. K. McDonald, Jun Sun et al.

 
 

Salmonella typhimurium is a major cause of diarrhea and causes significant morbidity and mortality worldwide, and perturbations of the gut microbiota are known to increase …

 
 
 
 
 
 

Multi-Omic Dynamics Associate Oxygenic Photosynthesis with Nitrogenase-Mediated H2 Production in Cyanothece sp. ATCC 51142

 
 

Hans C. Bernstein, Moiz A. Charania, Ryan S. McClure et al.

 
 

To date, the proposed mechanisms of nitrogenase-driven photosynthetic H2 production by the diazotrophic unicellular cyanobacterium Cyanothece sp. ATCC 51142 have assumed that …

 
 
 
 
 
 

Construction and analysis of dynamic transcription factor regulatory networks in the progression of glioma

 
 

Yongsheng Li, Tingting Shao, Chunjie Jiang et al.

 
 

The combinatorial cross-regulation of transcription factors (TFs) plays an important role in cellular identity and function; however, the dynamic regulation of TFs during glioma …

 
 
 
 
 
 

Mosaic patterns of diversification dynamics following the colonization of Melanesian islands

 
 

Emmanuel F. A. Toussaint, Lars Hendrich, Helena Shaverdo et al.

 
 

The fate of newly settled dispersers on freshly colonized oceanic islands is a central theme of island biogeography. The emergence of increasingly sophisticated methods of …

 
 
 
 
 
 

Measuring empathy for human and robot hand pain using electroencephalography

 
 

Yutaka Suzuki, Lisa Galli, Ayaka Ikeda et al.

 
 

This study provides the first physiological evidence of humans’ ability to empathize with robot pain and highlights the difference in empathy for humans and robots. We performed …

 
 
 
 
 
 

Interleukin-17 promotes angiogenesis by stimulating VEGF production of cancer cells via the STAT3/GIV signaling pathway in non-small-cell lung cancer

 
 

Bo Pan, Jing Shen, Jingyan Cao et al.

 
 

The presence of IL-17-positive cells is observed in a variety of inflammatory associated cancers and IL-17 has been found to be involved in angiogenesis. However, it remains …

 
 
 
 
 
 

Glucocorticoid (dexamethasone)-induced metabolome changes in healthy males suggest prediction of response and side effects

 
 

Natalie Bordag, Sebastian Klie, Kathrin Jürchott et al.

 
 

Glucocorticoids are indispensable anti-inflammatory and decongestant drugs with high prevalence of use at ~0.9% of the adult population. Better holistic insights into …

 
 
 
 
 
 

Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients

 
 

Jun Zeng, Xin Huang, Lina Zhou et al.

 
 

Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date. Characteristic metabolic deregulations of HCC may enable novel biomarkers discovery for early …

 
 
 
 
 
 

Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor

 
 

Shanshan Li, Weishan Wang, Xiao Li et al.

 
 

The lack of reliable reference genes (RGs) in the genus Streptomyces hampers effort to obtain the precise data of transcript levels. To address this issue, we aimed to identify …

 
 
 
 
 
 

Transcriptome analysis of genes involved in defence response in Polyporus umbellatus with Armillaria mellea infection

 
 

Meng-Meng Liu, Yong-Mei Xing, Da-Wei Zhang et al.

 
 

Polyporus umbellatus, a species symbiotic with Armillaria mellea and it also exhibits substantial defence response to Armillaria mellea infection. There are no genomics resources …

 
 
 
 
 
 

Biogeographical patterns of biomass allocation in leaves, stems, and roots in China’s forests

 
 

Hao Zhang, Kelin Wang, Xianli Xu et al.

 
 

To test whether there are general patterns in biomass partitioning in relation to environmental variation when stand biomass is considered, we investigated biomass allocation in …

 
 
 
 
 
 

The K167I variant of DNA polymerase β that is found in Esophageal Carcinoma patients impairs polymerase activity and BER

 
 

Yuanyuan Wang, Wenqiao Zang, Yuwen Du et al.

 
 

DNA polymerase β (pol β) is a key enzyme in DNA base excision repair, and an important factor for maintaining genomic integrity and stability. Esophageal carcinoma (EC) patients …

 
 
 
 
 
 

Transgenerational Developmental Programming of Ovarian Reserve

 
 

C. E. Aiken, J. L. Tarry-Adkins, S. E. Ozanne

 
 

Exposure to an adverse early-life environment leads to long-term health problems, many of which are recapitulated in subsequent generations. The female reproductive tract is …

 
 
 
 
 
 

The Plasmodium palmitoyl-S-acyl-transferase DHHC2 is essential for ookinete morphogenesis and malaria transmission

 
 

Jorge M. Santos, Jessica Kehrer, Blandine Franke-Fayard et al.

 
 

The post-translational addition of C-16 long chain fatty acids to protein cysteine residues is catalysed by palmitoyl-S-acyl-transferases (PAT) and affects the affinity of a …

 
 
 
 
 
 

Pollen-mediated gene flow from transgenic cotton under greenhouse conditions is dependent on different pollinators

 
 

Shuo Yan, Jialin Zhu, Weilong Zhu et al.

 
 

With the large-scale release of genetically modified (GM) crops, there are ecological concerns on transgene movement from GM crops to non-GM counterparts and wild relatives. In …

 
 
 
 
 
 

Intron V, not intron I of human thrombopoietin, improves expression in the milk of transgenic mice regulated by goat beta-casein promoter

 
 

Yan Li, Hu Hao, Mingqian Zhou et al.

 
 

Introns near 5′ end of genes generally enhance gene expression because of an enhancer /a promoter within their sequence or as intron-mediated enhancement. Surprisingly, our …

 
 
 
 
 
 

Crude oil as a microbial seed bank with unexpected functional potentials

 
 

Man Cai, Yong Nie, Chang-Qiao Chi et al.

 
 

It was widely believed that oil is a harsh habitat for microbes because of its high toxicity and hydrophobicity. However, accumulating evidence has revealed the presence of live …

 
 
 
 
 
 

SIMcheck: a Toolbox for Successful Super-resolution Structured Illumination Microscopy

 
 

Graeme Ball, Justin Demmerle, Rainer Kaufmann et al.

 
 

Three-dimensional structured illumination microscopy (3D-SIM) is a versatile and accessible method for super-resolution fluorescence imaging, but generating high-quality data is …

 
 
 
 
 
 

Diallyl disulfide attenuated carbon ion irradiation-induced apoptosis in mouse testis through changing the ratio of Tap73/ΔNp73 via mitochondrial pathway

 
 

Cui-xia Di, Lu Han, Hong Zhang et al.

 
 

Diallyl disulfide (DADS), a major organosulfur compound derived from garlic, has various biological properties, including anti-cancer effects. However, the protective mechanism …

 
 
 
 
 
 

Characterising the bacterial microbiota across the gastrointestinal tracts of dairy cattle: membership and potential function

 
 

Shengyong Mao, Mengling Zhang, Junhua Liu et al.

 
 

The bacterial community composition and function in the gastrointestinal tracts (GITs) of dairy cattle is very important, since it can influence milk production and host health. …

 
 
 
 
 
 

CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment

 
 

Qian-Qian Zhang, Xi-Wen Hu, Yi-Long Liu et al.

 
 

Mac-1 (CD11b) is expressed on bone marrow-derived immune cells. CD11b binds to ligands to regulate leukocyte adhesion and migration across the endothelium or epithelium. Here, we …

 
 
 
 
 
 

Biochemical and structural characterization of a novel ubiquitin-conjugating enzyme E2 from Agrocybe aegeria reveals Ube2w family-specific properties

 
 

Chao Qi, De-Feng Li, Lei Feng et al.

 
 

Ubiquitination is a post-translational modification that is involved in myriad cellar regulation and disease pathways. The ubiquitin-conjugating enzyme (E2) is an important …

 
 
 
 
 
 

Cognitive impairment in a young marmoset reveals lateral ventriculomegaly and a mild hippocampal atrophy: a case report

 
 

A. Sadoun, K. Strelnikov, E. Bonté et al.

 
 

The number of studies that use the common marmoset (Callithrix jacchus) in various fields of neurosciences is increasing dramatically. In general, animals enter the study when …

 
 
 
 
 
 

Fast-Response Calmodulin-Based Fluorescent Indicators Reveal Rapid Intracellular Calcium Dynamics

 
 

Nordine Helassa, Xiao-hua Zhang, Ianina Conte et al.

 
 

Faithful reporting of temporal patterns of intracellular Ca2+ dynamics requires the working range of indicators to match the signals. Current genetically encoded calmodulin-based …

 
 
 
 
 
 

pH and redox sensitive albumin hydrogel: A self-derived biomaterial

 
 

S Thirupathi Kumara Raja, T Thiruselvi, Asit Baran Mandal et al.

 
 

Serum albumin can be transformed to a stimuli (pH and redox) responsive hydrogel using the reduction process followed by oxidative refolding. The preparation of albumin hydrogel …

 
 
 
 
 
 

Natural transformation occurs independently of the essential actin-like MreB cytoskeleton in Legionella pneumophila

 
 

Pierre-Alexandre Juan, Laetitia Attaiech, Xavier Charpentier

 
 

Natural transformation is the process by which bacteria can actively take up and integrate exogenous DNA thereby providing a source of genetic diversity. Under specific growth …

 
 
 
 
 
 

Mouse adaptation of influenza B virus increases replication in the upper respiratory tract and results in droplet transmissibility in ferrets

 
 

Eun-Ha Kim, Su-Jin Park, Hyeok-Il Kwon et al.

 
 

To investigate the molecular changes that allow influenza B viruses to adapt to new mammalian hosts, influenza B/Florida/04/2006 was serially passaged in BALB/c mice until highly …

 
 
 
 
 
 

Ailanthone Inhibits Huh7 Cancer Cell Growth via Cell Cycle Arrest and Apoptosis In Vitro and In Vivo

 
 

Zhenjian Zhuo, Jianyang Hu, Xiaolin Yang et al.

 
 

While searching for natural anti-hepatocellular carcinoma (HCC) components in Ailanthus altissima, we discovered that ailanthone had potent antineoplastic activity against HCC. …

 
 
 
 
 
 

Ontogenetic development of the auditory sensory organ in zebrafish (Danio rerio): changes in hearing sensitivity and related morphology

 
 

Jiping Wang, Qiang Song, Dongzhen Yu et al.

 
 

Zebrafish (Danio rerio) is an important model organism in hearing research. However, data on the hearing sensitivity of zebrafish vary across different reports. In the present …

 
 
 
 
 
 

Annexin A2 binds to endosomes and negatively regulates TLR4-triggered inflammatory responses via the TRAM-TRIF pathway

 
 

Shuang Zhang, Min Yu, Qiang Guo et al.

 
 

Lipopolysaccharide (LPS) derived from Gram-negative bacteria activates plasma membrane signaling via Toll-like receptor 4 (TLR4) on host cells and triggers innate inflammatory …

 
 
 
 
 
 

Carbon mineralization pathways and bioturbation in coastal Brazilian sediments

 
 

Cintia O. Quintana, Maurício Shimabukuro, Camila O. Pereira et al.

 
 

Carbon mineralization processes and their dependence on environmental conditions (e.g. through macrobenthic bioturbation) have been widely studied in temperate coastal sediments, …

 
 
 
 
 
 

Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis, and possible involvement of the adenosine system

 
 

Mei-Liang Wang, Gang Yu, Shou-Pu Yi et al.

 
 

Incarvillea sinensis is a Bignoniaceae plant used to treat rheumatism and relieve pain in traditional Chinese medicine. As a major component of I. sinensis, incarvillateine has …

 
 
 
 
 
 

Adrenergic stimulation sensitizes TRPV1 through upregulation of cystathionine β-synthetase in a rat model of visceral hypersensitivity

 
 

Liyan Zhu, Liting Zhao, Ruobing Qu et al.

 
 

The pathogenesis of pain in irritable bowel syndrome (IBS) is poorly understood and treatment remains difficult. The present study was designed to investigate roles of adrenergic …

 
 
 
 
 
 

E. adenophorum induces Cell Cycle Arrest and Apoptosis of Splenocytes through the Mitochondrial Pathway and Caspase Activation in Saanen Goats

 
 

Yajun He, Quan Mo, Yanchun Hu et al.

 
 

The precise cytotoxicity of E. Adenophorum in relation to the cell cycle and apoptosis of splenocytes in Saanen goats remains unclear. In the present study, 16 Saanen goats were …

 
 
 
 
 
 

3D tracking of single nanoparticles and quantum dots in living cells by out-of-focus imaging with diffraction pattern recognition

 
 

Lucia Gardini, Marco Capitanio, Francesco S. Pavone

 
 

Live cells are three-dimensional environments where biological molecules move to find their targets and accomplish their functions. However, up to now, most single molecule …

 
 
 
 
 
 

NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis

 
 

Colin A. Bretz, Sara R. Savage, Megan E. Capozzi et al.

 
 

The objective of this study was to determine the role of individual NFAT isoforms in TNFα-induced retinal leukostasis. To this end, human retinal microvascular endothelial cells …

 
 
 
 
 
 

Bio-grout based on microbially induced sand solidification by means of asparaginase activity

 
 

Mengmeng Li, Qing-Long Fu, Qiuzhuo Zhang et al.

 
 

Bio-grout, a new ground improvement method, has been recently developed to improve the mechanical properties, decrease the permeability of porous materials, reinforce or repair …

 
 
 
 
 
 

Epithelial cell-derived micro RNA-146a generates interleukin-10-producing monocytes to inhibit nasal allergy

 
 

Xi Luo, Miaomiao Han, Jianqi Liu et al.

 
 

The aberrant immunity plays an important role in the pathogenesis of allergic diseases. Micro RNAs (miR) are involved in regulating the immunity in the body. This study aims to …

 
 
 
 
 
 

Genetic variants of SLC17A1 are associated with cholesterol homeostasis and hyperhomocysteinaemia in Japanese men

 
 

Teruhide Koyama, Daisuke Matsui, Nagato Kuriyama et al.

 
 

Hyperuricaemia is an undisputed and highly predictive biomarker for cardiovascular risk. SLC17A1, expressed in the liver and kidneys, harbours potent candidate single nucleotide …

 
 
 
 
 
 

Point-of-service, quantitative analysis of ascorbic acid in aqueous humor for evaluating anterior globe integrity

 
 

Manas R. Gartia, Santosh K. Misra, Mao Ye et al.

 
 

Limited training, high cost, and low equipment mobility leads to inaccuracies in decision making and is concerning with serious ocular injuries such as suspected ruptured globe …

 
 
 
 
 
 

Proteomic profiling of host-biofilm interactions in an oral infection model resembling the periodontal pocket

 
 

Kai Bao, Georgios N. Belibasakis, Nathalie Selevsek et al.

 
 

Periodontal infections cause inflammatory destruction of the tooth supporting tissues. We recently developed a dynamic, in vitro periodontal organotypic tissue model in a …

 
 
 
 
 
 

Identification of the active components in Bone Marrow Soup: a mitigator against irradiation-injury to salivary glands

 
 

Dongdong Fang, Shen Hu, Younan Liu et al.

 
 

In separate studies, an extract of soluble intracellular contents from whole bone marrow cells, named “Bone Marrow (BM) Soup”, was reported to either improve cardiac or salivary …

 
 
 
 
 
 
 
 
Nobel laureate in their own words

"Are you sitting comfortably? Then let me tell you about my Nobel prize-winning science."

In this series of animations, Nobel prize-winning scientists talk about work, life and discoveries that change the world. Recorded at the 65th Lindau Nobel Laureate Meeting.

Watch the animations free online. 

Supported by Mars, Incorporated
 
 
 
 
Chemical Sciences top
 
 
 
 
 
 
 

Anisotropic electronic conduction in stacked two-dimensional titanium carbide

 
 

Tao Hu, Hui Zhang, Jiemin Wang et al.

 
 

Stacked two-dimensional titanium carbide is an emerging conductive material for electrochemical energy storage which requires an understanding of the intrinsic electronic …

 
 
 
 
 
 

Synthesis of bi-phase dispersible core-shell FeAu@ZnO magneto-opto-fluorescent nanoparticles

 
 

Xue-Mei Li, Hong-Ling Liu, Xiao Liu et al.

 
 

Bi-phase dispersible core-shell FeAu@ZnO magneto-opto-fluorescent nanoparticles were synthesized by a modified nanoemulsion process using poly(ethylene …

 
 
 
 
 
 

A hierarchical view on material formation during pulsed-laser synthesis of nanoparticles in liquid

 
 

Shyjumon Ibrahimkutty, Philipp Wagener, Tomy dos Santos Rolo et al.

 
 

Pulsed-laser assisted nanoparticle synthesis in liquids (PLAL) is a versatile tool for nanoparticle synthesis. However, fundamental aspects of structure formation during PLAL are …

 
 
 
 
 
 

Microsphere integrated microfluidic disk: synergy of two techniques for rapid and ultrasensitive dengue detection

 
 

Samira Hosseini, Mohammad M. Aeinehvand, Shah M. Uddin et al.

 
 

The application of microfluidic devices in diagnostic systems is well-established in contemporary research. Large specific surface area of microspheres, on the other hand, has …

 
 
 
 
 
 

Two-State or Non-Two-State? An Excess Spectroscopy-based Approach to Differentiate the Existing Forms of Molecules in Liquids Mixtures

 
 

Yu Zhou, Yan-Zhen Zheng, Hai-Yuan Sun et al.

 
 

Characterization/identification of the clusters/associates in liquids has long been a challenging topic. In this paper, we report a method to identify molecules with two …

 
 
 
 
 
 

Intriguing Electrostatic Potential of CO: Negative Bond-ends and Positive Bond-cylindrical-surface

 
 

Hahn Kim, Van Dung Doan, Woo Jong Cho et al.

 
 

The strong electronegativity of O dictates that the ground state of singlet CO has positively charged C and negatively charged O, in agreement with ab initio charge analysis, but …

 
 
 
 
 
 

Innovative Strategy on Hydrogen Evolution Reaction Utilizing Activated Liquid Water

 
 

Bing-Joe Hwang, Hsiao-Chien Chen, Fu-Der Mai et al.

 
 

Splitting water for hydrogen production using light, or electrical energy, is the most developed ‘green technique’. For increasing efficiency in hydrogen production, currently, …

 
 
 
 
 
 

Metallocene Catalytic Insertion Polymerization of 1-Silene to Polycarbosilanes

 
 

Yuelong Tian, Min Ge, Weigang Zhang et al.

 
 

Metallocene of zirconium were used as a catalyst for an insertion polymerization of 1-methylsilene directly into pre-ceramic precursor polyzirconocenecarbosilane (PZCS) during …

 
 
 
 
 
 

Rapid identification of haloarchaea and methanoarchaea using the matrix assisted laser desorption/ionization time-of-flight mass spectrometry

 
 

Chao-Jen Shih, Sheng-Chung Chen, Chieh-Yin Weng et al.

 
 

The aim of this study was to classify certain environmental haloarchaea and methanoarchaea using matrix assisted laser desorption/ionization time-of-flight mass spectrometry …

 
 
 
 
 
 

A relay strategy for the mercury (II) chemodosimeter with ultra-sensitivity as test strips

 
 

Zhijun Ruan, Conggang Li, Jian-Rong Li et al.

 
 

A relay strategy has been proposed to design a new Hg2+ chemodosimeter (TPE-S), by coupling Hg2+-promoted deprotection reaction with ketone-enol isomerization, realizing the …

 
 
 
 
 
 

Versatile Molding Process for Tough Cellulose Hydrogel Materials

 
 

Mutsumi Kimura, Yoshie Shinohara, Junko Takizawa et al.

 
 

Shape-persistent and tough cellulose hydrogels were fabricated by a stepwise solvent exchange from a homogeneous ionic liquid solution of cellulose exposure to methanol vapor. …

 
 
 
 
 
 

Bio-inspired Construction of Advanced Fuel Cell Cathode with Pt Anchored in Ordered Hybrid Polymer Matrix

 
 

Zhangxun Xia, Suli Wang, Luhua Jiang et al.

 
 

The significant use of platinum for catalyzing the cathodic oxygen reduction reactions (ORRs) has hampered the widespread use of polymer electrolyte membrane fuel cells (PEMFCs). …

 
 
 
 
 
 

Platinized Graphene/ceramics Nano-sandwiched Architectures and Electrodes with Outstanding Performance for PEM Fuel Cells

 
 

Xu Chen, Daping He, Hui Wu et al.

 
 

For the first time a novel oxygen reduction catalyst with a 3D platinized graphene/nano-ceramic sandwiched architecture is successfully prepared by an unusual method. Herein the …

 
 
 
 
 
 

Manual control of catalytic reactions: Reactions by an apoenzyme gel and a cofactor gel

 
 

Yuichiro Kobayashi, Yoshinori Takashima, Akihito Hashidzume et al.

 
 

Enzymes play a vital role in catalysing almost all chemical reactions that occur in biological systems. Some enzymes must form complexes with non-protein molecules called …

 
 
 
 
 
 

Biomarker- and similarity coefficient-based approaches to bacterial mixture characterization using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS)

 
 

Lin Zhang, Sonja Smart, Todd R Sandrin

 
 

MALDI-TOF MS profiling has been shown to be a rapid and reliable method to characterize pure cultures of bacteria. Currently, there is keen interest in using this technique to …

 
 
 
 
 
 

Universal roles of hydrogen in electrochemical performance of graphene: high rate capacity and atomistic origins

 
 

Jianchao Ye, Mitchell T. Ong, Tae Wook Heo et al.

 
 

Atomic hydrogen exists ubiquitously in graphene materials made by chemical methods. Yet determining the effect of hydrogen on the electrochemical performance of graphene remains …

 
 
 
 
 
 

Smart protein biogate as a mediator to regulate competitive host-guest interaction for sensitive ratiometric electrochemical assay of prion

 
 

Peng Yu, Xiaohua Zhang, Jiawan Zhou et al.

 
 

A novel competitive host-guest strategy regulated by protein biogate was developed for sensitive and selective analysis of prion protein. The methylene blue (MB)-tagged prion …

 
 
 
 
 
 

Compressible and monolithic microporous polymer sponges prepared via one-pot synthesis

 
 

Yoonbin Lim, Min Chul Cha, Ji Young Chang

 
 

Compressible and monolithic microporous polymers (MPs) are reported. MPs were prepared as monoliths via a Sonogashira–Hagihara coupling reaction of 1,3,5-triethynylbenzene (TEB) …

 
 
 
 
 
 

A novel 2,5-diaminopyrimidine-based affinity probe for Bruton’s tyrosine kinase

 
 

Yingying Zuo, Yanxia Shi, Xitao Li et al.

 
 

As a critical regulator of the B-cell receptor signaling pathway, Bruton’s tyrosine kinase (Btk) has attracted intensive drug discovery efforts for treating B-cell lineage …

 
 
 
 
 
 

Bioinspired Reductionistic Peptide Engineering for Exceptional Mechanical Properties

 
 

M. B. Avinash, Devaraj Raut, Manish Kumar Mishra et al.

 
 

A simple solution-processing and self-assembly approach that exploits the synergistic interactions between multiple hydrogen bonded networks and aromatic interactions was …

 
 
 
 
 
 

Heterobimetallic Zeolite, InV-ZSM-5, Enables Efficient Conversion of Biomass Derived Ethanol to Renewable Hydrocarbons

 
 

Chaitanya K. Narula, Zhenglong Li, Erik M. Casbeer et al.

 
 

Direct catalytic conversion of ethanol to hydrocarbon blend-stock can increase biofuels use in current vehicles beyond the ethanol blend-wall of 10–15%. Literature reports …

 
 
 
 
 
 

Tuning the Reactivity of Radical through a Triplet Diradical Cu(II) Intermediate in Radical Oxidative Cross-Coupling

 
 

Liangliang Zhou, Hong Yi, Lei Zhu et al.

 
 

Highly selective radical/radical cross-coupling is paid more attention in bond formations. However, due to their intrinsic active properties, radical species are apt to achieve …

 
 
 
 
 
 

A novel approach combining self-organizing map and parallel factor analysis for monitoring water quality of watersheds under non-point source pollution

 
 

Yixiang Zhang, Xinqiang Liang, Zhibo Wang et al.

 
 

High content of organic matter in the downstream of watersheds underscored the severity of non-point source (NPS) pollution. The major objectives of this study were to …

 
 
 
 
 
 

Antiperovskite Chalco-Halides Ba3(FeS4)Cl, Ba3(FeS4)Br, and Ba3(FeSe4)Br with Spin Super-Super Exchange

 
 

Xian Zhang, Kai Liu, Jian-Qiao He et al.

 
 

Perovskite-related materials have received increasing attention for their broad applications in photovoltaic solar cells and information technology due to their unique electrical …

 
 
 
 
 
 

Electrodeposited Ultrathin TiO2 Blocking Layers for Efficient Perovskite Solar Cells

 
 

Tzu-Sen Su, Tsung-Yu Hsieh, Cheng-You Hong et al.

 
 

In this study, the electrodeposition (ED) of ultrathin, compact TiO2 blocking layers (BLs) on fluorine-doped tin oxide (FTO) glass for perovskite solar cells (PSCs) is evaluated. …

 
 
 
 
 
 
 
 

Nature Publishing Group offers a free open access funding support service to enable authors to discover and apply for article processing charge funding available to them.

Visit our website for further advice on the funding options available, and guidance in approaching funders and institutions, or email openaccess@nature.com for more information.

 
 
 
 
Physical Sciences top
 
 
 
 
 
 
 

Broadband and enhanced nonlinear optical response of MoS2/graphene nanocomposites for ultrafast photonics applications

 
 

Yaqin Jiang, Lili Miao, Guobao Jiang et al.

 
 

Due to their relatively high compatibility with specific photonic structures, strong light-matter interactions and unique nonlinear optical response, two-dimensional (2D) …

 
 
 
 
 
 

Anisotropic electronic conduction in stacked two-dimensional titanium carbide

 
 

Tao Hu, Hui Zhang, Jiemin Wang et al.

 
 

Stacked two-dimensional titanium carbide is an emerging conductive material for electrochemical energy storage which requires an understanding of the intrinsic electronic …

 
 
 
 
 
 

Frequency-noise measurements of optical frequency combs by multiple fringe-side discriminator

 
 

Nicola Coluccelli, Marco Cassinerio, Alessio Gambetta et al.

 
 

The frequency noise of an optical frequency comb is routinely measured through the hetherodyne beat of one comb tooth against a stable continuous-wave laser. After …

 
 
 
 
 
 

Spoof surface plasmon polaritons in terahertz transmission through subwavelength hole arrays analyzed by coupled oscillator model

 
 

Shan Yin, Xinchao Lu, Ningning Xu et al.

 
 

Both the localized resonance and excitation of spoof surface plasmon polaritons are observed in the terahertz transmission spectra of periodic subwavelength hole arrays. …

 
 
 
 
 
 

Synthesis of bi-phase dispersible core-shell FeAu@ZnO magneto-opto-fluorescent nanoparticles

 
 

Xue-Mei Li, Hong-Ling Liu, Xiao Liu et al.

 
 

Bi-phase dispersible core-shell FeAu@ZnO magneto-opto-fluorescent nanoparticles were synthesized by a modified nanoemulsion process using poly(ethylene …

 
 
 
 
 
 

A hierarchical view on material formation during pulsed-laser synthesis of nanoparticles in liquid

 
 

Shyjumon Ibrahimkutty, Philipp Wagener, Tomy dos Santos Rolo et al.

 
 

Pulsed-laser assisted nanoparticle synthesis in liquids (PLAL) is a versatile tool for nanoparticle synthesis. However, fundamental aspects of structure formation during PLAL are …

 
 
 
 
 
 

Electrically Tunable Epsilon-Near-Zero (ENZ) Metafilm Absorbers

 
 

Junghyun Park, Ju-Hyung Kang, Xiaoge Liu et al.

 
 

Enhancing and spectrally controlling light absorption is of great practical and fundamental importance. In optoelectronic devices consisting of layered semiconductors and metals, …

 
 
 
 
 
 

Shock assisted ionization injection in laser-plasma accelerators

 
 

C. Thaury, E. Guillaume, A. Lifschitz et al.

 
 

Ionization injection is a simple and efficient method to trap an electron beam in a laser plasma accelerator. Yet, because of a long injection length, this injection technique …

 
 
 
 
 
 

Photo-generated metamaterials induce modulation of CW terahertz quantum cascade lasers

 
 

Francesco P. Mezzapesa, Lorenzo L. Columbo, Carlo Rizza et al.

 
 

Periodic patterns of photo-excited carriers on a semiconductor surface profoundly modifies its effective permittivity, creating a stationary all-optical quasi-metallic …

 
 
 
 
 
 

Multimodal super-resolution optical microscopy visualizes the close connection between membrane and the cytoskeleton in liver sinusoidal endothelial cell fenestrations

 
 

Viola Mönkemöller, Cristina Øie, Wolfgang Hübner et al.

 
 

Liver sinusoidal endothelial cells (LSECs) act as a filter between blood and the hepatocytes. LSECs are highly fenestrated cells; they contain transcellular pores with diameters …

 
 
 
 
 
 

Enhancing the linear flow of fine granules through the addition of elongated particles

 
 

Zhiguo Guo, Xueli Chen, Yang Xu et al.

 
 

Sandglasses have been used to record time for thousands of years because of their constant flow rates; however, they now are drawing attention for their substantial scientific …

 
 
 
 
 
 

Quantum Metrology: Surpassing the shot-noise limit with Dzyaloshinskii-Moriya interaction

 
 

Fatih Ozaydin, Azmi Ali Altintas

 
 

Entanglement is at the heart of quantum technologies such as quantum information and quantum metrology. Providing larger quantum Fisher information (QFI), entangled systems can …

 
 
 
 
 
 

Topological, non-topological and instanton droplets driven by spin-transfer torque in materials with perpendicular magnetic anisotropy and Dzyaloshinskii–Moriya Interaction

 
 

Mario Carpentieri, Riccardo Tomasello, Roberto Zivieri et al.

 
 

The interfacial Dzyaloshinskii–Moriya Interaction can modify the topology of droplets excited by a localized spin-polarized current. Here, we show that, in addition to the …

 
 
 
 
 
 

A novel approach of high speed scratching on silicon wafers at nanoscale depths of cut

 
 

Zhenyu Zhang, Dongming Guo, Bo Wang et al.

 
 

In this study, a novel approach of high speed scratching is carried out on silicon (Si) wafers at nanoscale depths of cut to investigate the fundamental mechanisms in wafering of …

 
 
 
 
 
 

The determining factor of a preferred orientation of GaN domains grown on m-plane sapphire substrates

 
 

Miyeon Jue, Cheol-Woon Kim, Seoung-Hun Kang et al.

 
 

Epitaxial lateral overgrowth in tandem with the first-principles calculation was employed to investigate the determining factor of a preferred orientation of GaN on …

 
 
 
 
 
 

Highly Conductive Graphene/Ag Hybrid Fibers for Flexible Fiber-Type Transistors

 
 

Sang Su Yoon, Kang Eun Lee, Hwa-Jin Cha et al.

 
 

Mechanically robust, flexible, and electrically conductive textiles are highly suitable for use in wearable electronic applications. In this study, highly conductive and flexible …

 
 
 
 
 
 

Enhanced critical current density in the pressure-induced magnetic state of the high-temperature superconductor FeSe

 
 

Soon-Gil Jung, Ji-Hoon Kang, Eunsung Park et al.

 
 

We investigate the relation of the critical current density (Jc) and the remarkably increased superconducting transition temperature (Tc) for the FeSe single crystals under …

 
 
 
 
 
 

Tears of wine: new insights on an old phenomenon

 
 

David C. Venerus, David Nieto Simavilla

 
 

Anyone who has enjoyed a glass of wine has undoubtedly noticed the regular pattern of liquid beads that fall along the inside of the glass, or ‘tears of wine.’ The phenomenon is …

 
 
 
 
 
 

Spectroscopic characterization of charge carrier anisotropic motion in twisted few-layer graphene

 
 

Viktor Kandyba, Mikhail Yablonskikh, Alexei Barinov

 
 

Graphene, a layer of carbon atoms in a honeycomb lattice, captures enormous interest as probably the most promising component of future electronics thanks to its mechanical …

 
 
 
 
 
 

Generating multi-atom entangled W states via light-matter interface based fusion mechanism

 
 

Xue-Ping Zang, Ming Yang, Fatih Ozaydin et al.

 
 

W state is a key resource in quantum communication. Fusion technology has been proven to be a good candidate for preparing a large-size W state from two or more small-size W …

 
 
 
 
 
 

Relaxation damping in oscillating contacts

 
 

M. Popov, V.L. Popov, R. Pohrt

 
 

If a contact of two purely elastic bodies with no sliding (infinite coefficient of friction) is subjected to superimposed oscillations in the normal and tangential directions, …

 
 
 
 
 
 

Interface control by homoepitaxial growth in pulsed laser deposited iron chalcogenide thin films

 
 

Sebastian Molatta, Silvia Haindl, Sascha Trommler et al.

 
 

Thin film growth of iron chalcogenides by pulsed laser deposition (PLD) is still a delicate issue in terms of simultaneous control of stoichiometry, texture, substrate/film …

 
 
 
 
 
 

Observation of Landau levels on nitrogen-doped flat graphite surfaces without external magnetic fields

 
 

Takahiro Kondo, Donghui Guo, Taishi Shikano et al.

 
 

Under perpendicular external magnetic fields, two-dimensional carriers exhibit Landau levels (LLs). However, it has recently been reported that LLs have been observed on graphene …

 
 
 
 
 
 

Large-area functionalized CVD graphene for work function matched transparent electrodes

 
 

Thomas H. Bointon, Gareth F. Jones, Adolfo De Sanctis et al.

 
 

The efficiency of flexible photovoltaic and organic light emitting devices is heavily dependent on the availability of flexible and transparent conductors with at least a similar …

 
 
 
 
 
 

Hemicelluloses/montmorillonite hybrid films with improved mechanical and barrier properties

 
 

Ge-Gu Chen, Xian-Ming Qi, Ming-Peng Li et al.

 
 

A facile and environmentally friendly method was introduced to incorporate montmorillonite (MMT) as an inorganic phase into quaternized hemicelluloses (QH) for forming …

 
 
 
 
 
 

Ferritic Alloys with Extreme Creep Resistance via Coherent Hierarchical Precipitates

 
 

Gian Song, Zhiqian Sun, Lin Li et al.

 
 

There have been numerous efforts to develop creep-resistant materials strengthened by incoherent particles at high temperatures and stresses in response to future energy needs …

 
 
 
 
 
 

Selective protected state preparation of coupled dissipative quantum emitters

 
 

D. Plankensteiner, L. Ostermann, H. Ritsch et al.

 
 

Inherent binary or collective interactions in ensembles of quantum emitters induce a spread in the energy and lifetime of their eigenstates. While this typically causes fast …

 
 
 
 
 
 

Phase boundary of hot dense fluid hydrogen

 
 

Kenji Ohta, Kota Ichimaru, Mari Einaga et al.

 
 

We investigated the phase transformation of hot dense fluid hydrogen using static high-pressure laser-heating experiments in a laser-heated diamond anvil cell. The results show …

 
 
 
 
 
 

Accelerated CO2 transport on surface of AgO nanoparticles in ionic liquid BMIMBF4

 
 

Dahye Ji, Yong Soo Kang, Sang Wook Kang

 
 

The AgO nanoparticles were utilized for a CO2 separation membrane. The AgO nanoparticles were successfully generated in ionic liquid 1-butyl-3-methyl imidazolium …

 
 
 
 
 
 

Biological and immunotoxicity evaluation of antimicrobial peptide-loaded coatings using a layer-by-layer process on titanium

 
 

Jue Shi, Yu Liu, Ying Wang et al.

 
 

The prevention and control of peri-implantitis is a challenge in dental implant surgery. Dental implants with sustained antimicrobial coating are an ideal way of preventing …

 
 
 
 
 
 

Microsphere integrated microfluidic disk: synergy of two techniques for rapid and ultrasensitive dengue detection

 
 

Samira Hosseini, Mohammad M. Aeinehvand, Shah M. Uddin et al.

 
 

The application of microfluidic devices in diagnostic systems is well-established in contemporary research. Large specific surface area of microspheres, on the other hand, has …

 
 
 
 
 
 

Corrigendum: Communication activity in a social network: relation between long-term correlations and inter-event clustering

 
 

Diego Rybski, Sergey V. Buldyrev, Shlomo Havlin et al.

 
 

 
 
 
 
 
 

Innovative Strategy on Hydrogen Evolution Reaction Utilizing Activated Liquid Water

 
 

Bing-Joe Hwang, Hsiao-Chien Chen, Fu-Der Mai et al.

 
 

Splitting water for hydrogen production using light, or electrical energy, is the most developed ‘green technique’. For increasing efficiency in hydrogen production, currently, …

 
 
 
 
 
 

Reversible superconductor-insulator transition in LiTi2O4 induced by Li-ion electrochemical reaction

 
 

K. Yoshimatsu, M. Niwa, H. Mashiko et al.

 
 

Transition metal oxides display various electronic and magnetic phases such as high-temperature superconductivity. Controlling such exotic properties by applying an external …

 
 
 
 
 
 

Sub-wavelength Laser Nanopatterning using Droplet Lenses

 
 

Martí Duocastella, Camilo Florian, Pere Serra et al.

 
 

When a drop of liquid falls onto a screen, e.g. a cell phone, the pixels lying underneath appear magnified. This lensing effect is a combination of the curvature and refractive …

 
 
 
 
 
 

Metallocene Catalytic Insertion Polymerization of 1-Silene to Polycarbosilanes

 
 

Yuelong Tian, Min Ge, Weigang Zhang et al.

 
 

Metallocene of zirconium were used as a catalyst for an insertion polymerization of 1-methylsilene directly into pre-ceramic precursor polyzirconocenecarbosilane (PZCS) during …

 
 
 
 
 
 

Two-State or Non-Two-State? An Excess Spectroscopy-based Approach to Differentiate the Existing Forms of Molecules in Liquids Mixtures

 
 

Yu Zhou, Yan-Zhen Zheng, Hai-Yuan Sun et al.

 
 

Characterization/identification of the clusters/associates in liquids has long been a challenging topic. In this paper, we report a method to identify molecules with two …

 
 
 
 
 
 

Intriguing Electrostatic Potential of CO: Negative Bond-ends and Positive Bond-cylindrical-surface

 
 

Hahn Kim, Van Dung Doan, Woo Jong Cho et al.

 
 

The strong electronegativity of O dictates that the ground state of singlet CO has positively charged C and negatively charged O, in agreement with ab initio charge analysis, but …

 
 
 
 
 
 

A General Time-Periodic Driving Approach to Realize Topological Phases in Cold Atomic Systems

 
 

Zhongbo Yan, Bo Li, Xiaosen Yang et al.

 
 

For time-reversal symmetric cold atomic insulating systems, it is found that the usual driving approach based on electromagnetic field used in solid state systems loses its power …

 
 
 
 
 
 

Strengthening behavior of carbon/metal nanocomposites

 
 

S. E. Shin, H. J. Choi, J. Y. Hwang et al.

 
 

Nanocomposites reinforced with nano-scale reinforcements exhibit excellent mechanical properties with low volume fraction of the reinforcement. For instance, only an addition of …

 
 
 
 
 
 

A relay strategy for the mercury (II) chemodosimeter with ultra-sensitivity as test strips

 
 

Zhijun Ruan, Conggang Li, Jian-Rong Li et al.

 
 

A relay strategy has been proposed to design a new Hg2+ chemodosimeter (TPE-S), by coupling Hg2+-promoted deprotection reaction with ketone-enol isomerization, realizing the …

 
 
 
 
 
 

X–ray absorption, phase and dark–field tomography through a beam tracking approach

 
 

Fabio A. Vittoria, Marco Endrizzi, Paul C. Diemoz et al.

 
 

We present a development of the beam–tracking approach that allows its implementation in computed tomography. One absorbing mask placed before the sample and a high resolution …

 
 
 
 
 
 

Micro-metric electronic patterning of a topological band structure using a photon beam

 
 

E. Frantzeskakis, N. De Jong, B. Zwartsenberg et al.

 
 

In an ideal 3D topological insulator (TI), the bulk is insulating and the surface conducting due to the existence of metallic states that are localized on the surface; these are …

 
 
 
 
 
 

Heteroepitaxial Cu2O thin film solar cell on metallic substrates

 
 

Sung Hun Wee, Po-Shun Huang, Jung-Kun Lee et al.

 
 

Heteroepitaxial, single-crystal-like Cu2O films on inexpensive, flexible, metallic substrates can potentially be used as absorber layers for fabrication of low-cost, …

 
 
 
 
 
 

Rapid identification of haloarchaea and methanoarchaea using the matrix assisted laser desorption/ionization time-of-flight mass spectrometry

 
 

Chao-Jen Shih, Sheng-Chung Chen, Chieh-Yin Weng et al.

 
 

The aim of this study was to classify certain environmental haloarchaea and methanoarchaea using matrix assisted laser desorption/ionization time-of-flight mass spectrometry …

 
 
 
 
 
 

De novo protein conformational sampling using a probabilistic graphical model

 
 

Debswapna Bhattacharya, Jianlin Cheng

 
 

Efficient exploration of protein conformational space remains challenging especially for large proteins when assembling discretized structural fragments extracted from a protein …

 
 
 
 
 
 

Brain size regulations by cbp haploinsufficiency evaluated by in-vivo MRI based volumetry

 
 

Juan C. Ateca-Cabarga, Alejandro Cosa, Vicente Pallarés et al.

 
 

The Rubinstein-Taybi Syndrome (RSTS) is a congenital disease that affects brain development causing severe cognitive deficits. In most cases the disease is associated with …

 
 
 
 
 
 

Targeted, noninvasive blockade of cortical neuronal activity

 
 

Nathan McDannold, Yongzhi Zhang, Chanikarn Power et al.

 
 

Here we describe a novel method to noninvasively modulate targeted brain areas through the temporary disruption of the blood-brain barrier (BBB) via focused ultrasound, enabling …

 
 
 
 
 
 

A method for estimating spikelet number per panicle: Integrating image analysis and a 5-point calibration model

 
 

Sanqin Zhao, Jiabing Gu, Youyong Zhao et al.

 
 

Spikelet number per panicle (SNPP) is one of the most important yield components used to estimate rice yields. The use of high-throughput quantitative image analysis methods for …

 
 
 
 
 
 

Increased costs reduce reciprocal helping behaviour of humans in a virtual evacuation experiment

 
 

Nikolai W. F. Bode, Jordan Miller, Rick O’Gorman et al.

 
 

Altruistic behaviour is widespread and highly developed in humans and can also be found in some animal species. It has been suggested that altruistic tendencies can depend on …

 
 
 
 
 
 

Bio-inspired Construction of Advanced Fuel Cell Cathode with Pt Anchored in Ordered Hybrid Polymer Matrix

 
 

Zhangxun Xia, Suli Wang, Luhua Jiang et al.

 
 

The significant use of platinum for catalyzing the cathodic oxygen reduction reactions (ORRs) has hampered the widespread use of polymer electrolyte membrane fuel cells (PEMFCs). …

 
 
 
 
 
 

Soft resonator of omnidirectional resonance for acoustic metamaterials with a negative bulk modulus

 
 

Xiaodong Jing, Yang Meng, Xiaofeng Sun

 
 

Monopolar resonance is of fundamental importance in the acoustic field. Here, we present the realization of a monopolar resonance that goes beyond the concept of Helmholtz …

 
 
 
 
 
 

Platinized Graphene/ceramics Nano-sandwiched Architectures and Electrodes with Outstanding Performance for PEM Fuel Cells

 
 

Xu Chen, Daping He, Hui Wu et al.

 
 

For the first time a novel oxygen reduction catalyst with a 3D platinized graphene/nano-ceramic sandwiched architecture is successfully prepared by an unusual method. Herein the …

 
 
 
 
 
 

Manual control of catalytic reactions: Reactions by an apoenzyme gel and a cofactor gel

 
 

Yuichiro Kobayashi, Yoshinori Takashima, Akihito Hashidzume et al.

 
 

Enzymes play a vital role in catalysing almost all chemical reactions that occur in biological systems. Some enzymes must form complexes with non-protein molecules called …

 
 
 
 
 
 

The Frenkel Line: a direct experimental evidence for the new thermodynamic boundary

 
 

Dima Bolmatov, Mikhail Zhernenkov, Dmitry Zav’yalov et al.

 
 

Supercritical fluids play a significant role in elucidating fundamental aspects of liquid matter under extreme conditions. They have been extensively studied at pressures and …

 
 
 
 
 
 

Predicted Growth of Two-Dimensional Topological Insulator Thin Films of III-V Compounds on Si(111) Substrate

 
 

Liang-Zi Yao, Christian P. Crisostomo, Chun-Chen Yeh et al.

 
 

We have carried out systematic first-principles electronic structure computations of growth of ultrathin films of compounds of group III (B, Al, In, Ga, and Tl) with group V (N, …

 
 
 
 
 
 

Molecular dynamics investigations of mechanical behaviours in monocrystalline silicon due to nanoindentation at cryogenic temperatures and room temperature

 
 

Xiancheng Du, Hongwei Zhao, Lin Zhang et al.

 
 

Molecular dynamics simulations of nanoindentation tests on monocrystalline silicon (010) surface were conducted to investigate the mechanical properties and deformation mechanism …

 
 
 
 
 
 

Versatile Molding Process for Tough Cellulose Hydrogel Materials

 
 

Mutsumi Kimura, Yoshie Shinohara, Junko Takizawa et al.

 
 

Shape-persistent and tough cellulose hydrogels were fabricated by a stepwise solvent exchange from a homogeneous ionic liquid solution of cellulose exposure to methanol vapor. …

 
 
 
 
 
 

Remote control of self-assembled microswimmers

 
 

G. Grosjean, G. Lagubeau, A. Darras et al.

 
 

Physics governing the locomotion of microorganisms and other microsystems is dominated by viscous damping. An effective swimming strategy involves the non-reciprocal and periodic …

 
 
 
 
 
 

Surface and Bulk Carbide Transformations in High-Speed Steel

 
 

M. Godec, T. Večko Pirtovšek, B. Šetina Batič et al.

 
 

We have studied the transformation of carbides in AISI M42 high-speed steels in the temperature window used for forging. The annealing was found to result in the partial …

 
 
 
 
 
 

Quantification of dislocation nucleation stress in TiN through high-resolution in situ indentation experiments and first principles calculations

 
 

N. Li, S.K. Yadav, X.-Y. Liu et al.

 
 

Through in situ indentation of TiN in a high-resolution transmission electron microscope, the nucleation of full as well as partial dislocations has been observed from {001} and …

 
 
 
 
 
 

An integrative quantifier of multistability in complex systems based on ecological resilience

 
 

Chiranjit Mitra, Jürgen Kurths, Reik V. Donner

 
 

The abundance of multistable dynamical systems calls for an appropriate quantification of the respective stability of the (stable) states of such systems. Motivated by the …

 
 
 
 
 
 

Strain-driven band inversion and topological aspects in Antimonene

 
 

Mingwen Zhao, Xiaoming Zhang, Linyang Li

 
 

Searching for the two-dimensional (2D) topological insulators (TIs) with large bulk band gaps is the key to achieve room-temperature quantum spin Hall effect (QSHE). Using …

 
 
 
 
 
 

Fano resonance assisting plasmonic circular dichroism from nanorice heterodimers for extrinsic chirality

 
 

Li Hu, Yingzhou Huang, Liang Fang et al.

 
 

In this work, the circular dichroisms (CD) of nanorice heterodimers consisting of two parallel arranged nanorices with the same size but different materials are investigated …

 
 
 
 
 
 

Temperature dependence of Coulomb oscillations in a few-layer two-dimensional WS2 quantum dot

 
 

Xiang-Xiang Song, Zhuo-Zhi Zhang, Jie You et al.

 
 

Standard semiconductor fabrication techniques are used to fabricate a quantum dot (QD) made of WS2, where Coulomb oscillations were found. The full-width-at-half-maximum of the …

 
 
 
 
 
 

Ultra-flexible Piezoelectric Devices Integrated with Heart to Harvest the Biomechanical Energy

 
 

Bingwei Lu, Ying Chen, Dapeng Ou et al.

 
 

Power supply for medical implantable devices (i.e. pacemaker) always challenges not only the surgery but also the battery technology. Here, we report a strategy for energy …

 
 
 
 
 
 

Nano-sized precipitate stability and its controlling factors in a NiAl-strengthened ferritic alloy

 
 

Zhiqian Sun, Gian Song, Jan Ilavsky et al.

 
 

Coherent B2-ordered NiAl-type precipitates have been used to reinforce solid-solution body-centered-cubic iron for high-temperature application in fossil-energy power plants. In …

 
 
 
 
 
 

Single Crystalline Film of Hexagonal Boron Nitride Atomic Monolayer by Controlling Nucleation Seeds and Domains

 
 

Qinke Wu, Ji-Hoon Park, Sangwoo Park et al.

 
 

A monolayer hexagonal boron nitride (h-BN) film with controllable domain morphology and domain size (varying from less than 1 μm to more than 100 μm) with uniform crystalline …

 
 
 
 
 
 

Integrated active sensor system for real time vibration monitoring

 
 

Qijie Liang, Xiaoqin Yan, Xinqin Liao et al.

 
 

We report a self-powered, lightweight and cost-effective active sensor system for vibration monitoring with multiplexed operation based on contact electrification between sensor …

 
 
 
 
 
 

Green synthesis of in situ electrodeposited rGO/MnO2 nanocomposite for high energy density supercapacitors

 
 

Rusi, S. R. Majid

 
 

This paper presents the preparation of in situ electrodeposited rGO/MnO2 nanocomposite as a binder-free electrode for supercapacitor application. The work describes and evaluates …

 
 
 
 
 
 

Mesoporous gold sponges: electric charge-assisted seed mediated synthesis and application as surface-enhanced Raman scattering substrates

 
 

Zao Yi, Jiangshan Luo, Xiulan Tan et al.

 
 

Mesoporous gold sponges were prepared using 4-dimethylaminopyridine (DMAP)-stabilized Au seeds. This is a general process, which involves a simple template-free method, room …

 
 
 
 
 
 

Stabilization of magnetic helix in exchange-coupled thin films

 
 

L. V. Dzemiantsova, G. Meier, R. Röhlsberger

 
 

Based on micromagnetic simulations, we report on a novel magnetic helix in a soft magnetic film that is sandwiched between and exchange-coupled to two hard magnetic layers with …

 
 
 
 
 
 

Universal roles of hydrogen in electrochemical performance of graphene: high rate capacity and atomistic origins

 
 

Jianchao Ye, Mitchell T. Ong, Tae Wook Heo et al.

 
 

Atomic hydrogen exists ubiquitously in graphene materials made by chemical methods. Yet determining the effect of hydrogen on the electrochemical performance of graphene remains …

 
 
 
 
 
 

Quantification of NS1 dengue biomarker in serum via optomagnetic nanocluster detection

 
 

Paula Antunes, Daniel Watterson, Mattias Parmvi et al.

 
 

Dengue is a tropical vector-borne disease without cure or vaccine that progressively spreads into regions with temperate climates. Diagnostic tools amenable to resource-limited …

 
 
 
 
 
 

Biomarker- and similarity coefficient-based approaches to bacterial mixture characterization using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS)

 
 

Lin Zhang, Sonja Smart, Todd R Sandrin

 
 

MALDI-TOF MS profiling has been shown to be a rapid and reliable method to characterize pure cultures of bacteria. Currently, there is keen interest in using this technique to …

 
 
 
 
 
 

Mutual and asynchronous anticipation and action in sports as globally competitive and locally coordinative dynamics

 
 

Keisuke Fujii, Tadao Isaka, Motoki Kouzaki et al.

 
 

Humans interact by changing their actions, perceiving other’s actions and executing solutions in conflicting situations. Using oscillator models, nonlinear dynamics have been …

 
 
 
 
 
 

Corrigendum: Origins of power-law degree distribution in the heterogeneity of human activity in social networks

 
 

Lev Muchnik, Sen Pei, Lucas C. Parra et al.

 
 

 
 
 
 
 
 

All-fibre photonic signal generator for attosecond timing and ultralow-noise microwave

 
 

Kwangyun Jung, Jungwon Kim

 
 

High-impact frequency comb applications that are critically dependent on precise pulse timing (i.e., repetition rate) have recently emerged and include the synchronization of …

 
 
 
 
 
 

Strong Optomechanical Coupling in Nanobeam Cavities based on Hetero Optomechanical Crystals

 
 

Zhilei Huang, Kaiyu Cui, Yongzhuo Li et al.

 
 

Nanobeam cavities based on hetero optomechanical crystals are proposed. With optical and mechanical modes separately confined by two types of periodic structures, the mechanical …

 
 
 
 
 
 

Corrigendum: Structural Evolution of Chemically-Driven RuO2 Nanowires and 3-Dimensional Design for Photo-Catalytic Applications

 
 

Joonmo Park, Jae Won Lee, Byeong Uk Ye et al.

 
 

 
 
 
 
 
 

Flexible CNT-array double helices Strain Sensor with high stretchability for Motion Capture

 
 

Cheng Li, Ya-Long Cui, Gui-Li Tian et al.

 
 

Motion capture is attracting more and more attention due to its potential wide applications in various fields. However, traditional methods for motion capture still have weakness …

 
 
 
 
 
 

Self-regulated oscillation of transport and topology of magnetic islands in toroidal plasmas

 
 

K. Ida, T. Kobayashi, T. E. Evans et al.

 
 

The coupling between the transport and magnetic topology is an important issue because the structure of magnetic islands, embedded in a toroidal equilibrium field, depends on the …

 
 
 
 
 
 

Experimental Demonstration of Anomalous Field Enhancement in All-Dielectric Transition Magnetic Metamaterials

 
 

Jingbo Sun, Xiaoming Liu, Ji Zhou et al.

 
 

Anomalous field enhancement accompanied by resonant absorption phenomenon was originally discussed in the context of plasma physics and in applications related to …

 
 
 
 
 
 

Double-twist cylinders in liquid crystalline cholesteric blue phases observed by transmission electron microscopy

 
 

Shu Tanaka, Hiroyuki Yoshida, Yuto Kawata et al.

 
 

Cholesteric blue phases are liquid crystalline phases in which the constituent rod-like molecules spontaneously form three-dimensional, helical structures. Despite theoretical …

 
 
 
 
 
 

Compressible and monolithic microporous polymer sponges prepared via one-pot synthesis

 
 

Yoonbin Lim, Min Chul Cha, Ji Young Chang

 
 

Compressible and monolithic microporous polymers (MPs) are reported. MPs were prepared as monoliths via a Sonogashira–Hagihara coupling reaction of 1,3,5-triethynylbenzene (TEB) …

 
 
 
 
 
 

One-dimensional sawtooth and zigzag lattices for ultracold atoms

 
 

Ting Zhang, Gyu-Boong Jo

 
 

We describe tunable optical sawtooth and zigzag lattices for ultracold atoms. Making use of the superlattice generated by commensurate wavelengths of light beams, tunable …

 
 
 
 
 
 

On-chip optical mode exchange using tapered directional coupler

 
 

Zhonglai Zhang, Xiao Hu, Jian Wang

 
 

We present an on-chip optical mode exchange between two multiplexed modes by using tapered directional couplers on silicon-on-insulator platform. The device consisting of mode …

 
 
 
 
 
 

Smart protein biogate as a mediator to regulate competitive host-guest interaction for sensitive ratiometric electrochemical assay of prion

 
 

Peng Yu, Xiaohua Zhang, Jiawan Zhou et al.

 
 

A novel competitive host-guest strategy regulated by protein biogate was developed for sensitive and selective analysis of prion protein. The methylene blue (MB)-tagged prion …

 
 
 
 
 
 

Biometamaterials: Black Ultrathin Gold Film Fabricated on Lotus Leaf

 
 

Yuusuke Ebihara, Ryoichi Ota, Takahiro Noriki et al.

 
 

We report on a black metamaterial of gold fabricated on a lotus leaf that was used as a template. In spite of the extremely thin gold coating (10-nm thick) on the lotus leaf, the …

 
 
 
 
 
 

Strain assisted electrocaloric effect in PbZr0.95Ti0.05O3 films on 0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3 substrate

 
 

Zhenghu Zuo, Bin Chen, Baomin Wang et al.

 
 

Solid state cooling technologies based on electrocaloric, magnetocaloric and mechanocaloric effects have received much attention during the past decade. To further improve the …

 
 
 
 
 
 

Graphene wrinkling induced by monodisperse nanoparticles: facile control and quantification

 
 

Jana Vejpravova, Barbara Pacakova, Jan Endres et al.

 
 

Controlled wrinkling of single-layer graphene (1-LG) at nanometer scale was achieved by introducing monodisperse nanoparticles (NPs), with size comparable to the strain coherence …

 
 
 
 
 
 

VO2/TiO2 Nanosponges as Binder-Free Electrodes for High-Performance Supercapacitors

 
 

Chenchen Hu, Henghui Xu, Xiaoxiao Liu et al.

 
 

VO2/TiO2 nanosponges with easily tailored nanoarchitectures and composition were synthesized by electrostatic spray deposition as binder-free electrodes for supercapacitors. …

 
 
 
 
 
 

Light-matter decoupling and A2 term detection in superconducting circuits

 
 

J. J. García-Ripoll, B. Peropadre, S. De Liberato

 
 

The spontaneous and stimulated emission of a superconducting qubit in the presence of propagating microwaves originates from an effective light-matter interaction that, similarly …

 
 
 
 
 
 

Nonlinear restoration of pulse and high noisy images via stochastic resonance

 
 

Qibing Sun, Hongjun Liu, Nan Huang et al.

 
 

We propose a novel scheme for restoring pulse and high noisy images using stochastic resonance, which is based on the modulation instability and provides a cross-correlation gain …

 
 
 
 
 
 

Optical fiber tip templating using direct focused ion beam milling

 
 

A. Micco, A. Ricciardi, M. Pisco et al.

 
 

We report on a method for integrating sub-wavelength resonant structures on top of optical fiber tip. Our fabrication technique is based on direct milling of the glass on the …

 
 
 
 
 
 

Modifying the thermal conductivity of small molecule organic semiconductor thin films with metal nanoparticles

 
 

Xinyu Wang, Kevin D. Parrish, Jonathan A. Malen et al.

 
 

Thermal properties of organic semiconductors play a significant role in the performance and lifetime of organic electronic devices, especially for scaled-up large area …

 
 
 
 
 
 

Extraordinary high ductility/strength of the interface designed bulk W-ZrC alloy plate at relatively low temperature

 
 

Z. M. Xie, R. Liu, S. Miao et al.

 
 

The refractory tungsten alloys with high ductility/strength/plasticity are highly desirable for a wide range of critical applications. Here we report an interface design strategy …

 
 
 
 
 
 

Electrical Double Layer Capacitance in a Graphene-embedded Al2O3 Gate Dielectric

 
 

Bok Ki Min, Seong K. Kim, Seong Jun Kim et al.

 
 

Graphene heterostructures are of considerable interest as a new class of electronic devices with exceptional performance in a broad range of applications has been realized. Here, …

 
 
 
 
 
 

Tilt engineering of exchange coupling at G-type SrMnO3/(La,Sr)MnO3 interfaces

 
 

F. Li, C. Song, Y. Y. Wang et al.

 
 

With the recent realization of hybrid improper ferroelectricity and room-temperature multiferroic by tilt engineering, “functional” octahedral tilting has become a novel concept …

 
 
 
 
 
 

Probing Nanoscale Thermal Transport in Surfactant Solutions

 
 

Fangyu Cao, Ying Liu, Jiajun Xu et al.

 
 

Surfactant solutions typically feature tunable nanoscale, internal structures. Although rarely utilized, they can be a powerful platform for probing thermal transport in …

 
 
 
 
 
 

A novel 2,5-diaminopyrimidine-based affinity probe for Bruton’s tyrosine kinase

 
 

Yingying Zuo, Yanxia Shi, Xitao Li et al.

 
 

As a critical regulator of the B-cell receptor signaling pathway, Bruton’s tyrosine kinase (Btk) has attracted intensive drug discovery efforts for treating B-cell lineage …

 
 
 
 
 
 

Highly sensitive image-derived indices of water-stressed plants using hyperspectral imaging in SWIR and histogram analysis

 
 

David M. Kim, Hairong Zhang, Haiying Zhou et al.

 
 

The optical signature of leaves is an important monitoring and predictive parameter for a variety of biotic and abiotic stresses, including drought. Such signatures derived from …

 
 
 
 
 
 

Dynamic nano-imaging of label-free living cells using electron beam excitation-assisted optical microscope

 
 

Masahiro Fukuta, Satoshi Kanamori, Taichi Furukawa et al.

 
 

Optical microscopes are effective tools for cellular function analysis because biological cells can be observed non-destructively and non-invasively in the living state in either …

 
 
 
 
 
 

Bioinspired Reductionistic Peptide Engineering for Exceptional Mechanical Properties

 
 

M. B. Avinash, Devaraj Raut, Manish Kumar Mishra et al.

 
 

A simple solution-processing and self-assembly approach that exploits the synergistic interactions between multiple hydrogen bonded networks and aromatic interactions was …

 
 
 
 
 
 

3D tracking of single nanoparticles and quantum dots in living cells by out-of-focus imaging with diffraction pattern recognition

 
 

Lucia Gardini, Marco Capitanio, Francesco S. Pavone

 
 

Live cells are three-dimensional environments where biological molecules move to find their targets and accomplish their functions. However, up to now, most single molecule …

 
 
 
 
 
 

Welding of Semiconductor Nanowires by Coupling Laser-Induced Peening and Localized Heating

 
 

Kelly M. Rickey, Qiong Nian, Genqiang Zhang et al.

 
 

We demonstrate that laser peening coupled with sintering of CdTe nanowire films substantially enhances film quality and charge transfer while largely maintaining basic particle …

 
 
 
 
 
 

Non-Contact Measurement of Thermal Diffusivity in Ion-Implanted Nuclear Materials

 
 

F. Hofmann, D. R. Mason, J. K. Eliason et al.

 
 

Knowledge of mechanical and physical property evolution due to irradiation damage is essential for the development of future fission and fusion reactors. Ion-irradiation provides …

 
 
 
 
 
 

Experimental simulation of decoherence in photonics qudits

 
 

B. Marques, A. A. Matoso, W. M. Pimenta et al.

 
 

We experimentally perform the simulation of open quantum dynamics in single-qudit systems. Using a spatial light modulator as a dissipative optical device, we implement …

 
 
 
 
 
 

Thickness effect of ultra-thin Ta2O5 resistance switching layer in 28 nm-diameter memory cell

 
 

Tae Hyung Park, Seul Ji Song, Hae Jin Kim et al.

 
 

Resistance switching (RS) devices with ultra-thin Ta2O5 switching layer (0.5–2.0 nm) with a cell diameter of 28 nm were fabricated. The performance of the devices was tested by …

 
 
 
 
 
 

Origins of Highly Stable Al-evaporated Solution-processed ZnO Thin Film Transistors: Insights from Low Frequency and Random Telegraph Signal Noise

 
 

Joo Hyung Kim, Tae Sung Kang, Jung Yup Yang et al.

 
 

One long-standing goal in the emerging field of flexible and transparent electronic devices is to meet the demand of key markets, such as enhanced output performance for metal …

 
 
 
 
 
 

Dual-channel near-field control by polarizations using isotropic and inhomogeneous metasurface

 
 

Xiang Wan, Ben Geng Cai, Yun Bo Li et al.

 
 

We propose a method for dual-channel near-field manipulations by designing isotropic but inhomogeneous metasurfaces. As example, we present a dual-channel near-field focusing …

 
 
 
 
 
 

High throughput optical lithography by scanning a massive array of bowtie aperture antennas at near-field

 
 

X. Wen, A. Datta, L. M. Traverso et al.

 
 

Optical lithography, the enabling process for defining features, has been widely used in semiconductor industry and many other nanotechnology applications. Advances of …

 
 
 
 
 
 

Heterobimetallic Zeolite, InV-ZSM-5, Enables Efficient Conversion of Biomass Derived Ethanol to Renewable Hydrocarbons

 
 

Chaitanya K. Narula, Zhenglong Li, Erik M. Casbeer et al.

 
 

Direct catalytic conversion of ethanol to hydrocarbon blend-stock can increase biofuels use in current vehicles beyond the ethanol blend-wall of 10–15%. Literature reports …

 
 
 
 
 
 

Understanding the structural transformation, stability of medium-sized neutral and charged silicon clusters

 
 

Li Ping Ding, Fang Hui Zhang, Yong Sheng Zhu et al.

 
 

The structural and electronic properties for the global minimum structures of medium-sized neutral, anionic and cationic Sinμ (n = 20–30, μ = 0, −1 and +1) clusters have been …

 
 
 
 
 
 

Antiperovskite Chalco-Halides Ba3(FeS4)Cl, Ba3(FeS4)Br, and Ba3(FeSe4)Br with Spin Super-Super Exchange

 
 

Xian Zhang, Kai Liu, Jian-Qiao He et al.

 
 

Perovskite-related materials have received increasing attention for their broad applications in photovoltaic solar cells and information technology due to their unique electrical …

 
 
 
 
 
 

Electrodeposited Ultrathin TiO2 Blocking Layers for Efficient Perovskite Solar Cells

 
 

Tzu-Sen Su, Tsung-Yu Hsieh, Cheng-You Hong et al.

 
 

In this study, the electrodeposition (ED) of ultrathin, compact TiO2 blocking layers (BLs) on fluorine-doped tin oxide (FTO) glass for perovskite solar cells (PSCs) is evaluated. …

 
 
 
 
 
 

Atomic mapping of Ruddlesden-Popper faults in transparent conducting BaSnO3-based thin films

 
 

W. Y. Wang, Y. L. Tang, Y. L. Zhu et al.

 
 

Doped BaSnO3 has arisen many interests recently as one of the promising transparent conducting oxides for future applications. Understanding the microstructural characteristics …

 
 
 
 
 
 

UV-Enhanced Sacrificial Layer Stabilised Graphene Oxide Hollow Fibre Membranes for Nanofiltration

 
 

J. Y. Chong, N. F. D. Aba, B. Wang et al.

 
 

Graphene oxide (GO) membranes have demonstrated great potential in gas separation and liquid filtration. For upscale applications, GO membranes in a hollow fibre geometry are of …

 
 
 
 
 
 

Micro-structural Change During Nucleation: From Nucleus To Bicontinuous Morphology

 
 

Seongmin Jeong, Yongseok Jho, Xin Zhou

 
 

Although the microstructure of coexistence phase provides direct insights of the nucleation mechanism and their change is substantial in the phase transition, their study is …

 
 
 
 
 
 

Plastic straw: future of high-speed signaling

 
 

Ha Il Song, Huxian Jin, Hyeon-Min Bae

 
 

The ever-increasing demand for bandwidth triggered by mobile and video Internet traffic requires advanced interconnect solutions satisfying functional and economic constraints. A …

 
 
 
 
 
 

Electron-Selective TiO2 Contact for Cu(In,Ga)Se2 Solar Cells

 
 

Weitse Hsu, Carolin M. Sutter-Fella, Mark Hettick et al.

 
 

The non-toxic and wide bandgap material TiO2 is explored as an n-type buffer layer on p-type Cu(In,Ga)Se2 (CIGS) absorber layer for thin film solar cells. The amorphous TiO2 thin …

 
 
 
 
 
 

Tuning the Reactivity of Radical through a Triplet Diradical Cu(II) Intermediate in Radical Oxidative Cross-Coupling

 
 

Liangliang Zhou, Hong Yi, Lei Zhu et al.

 
 

Highly selective radical/radical cross-coupling is paid more attention in bond formations. However, due to their intrinsic active properties, radical species are apt to achieve …

 
 
 
 
 
 

Electronic structure of quasi-one-dimensional superconductor K2Cr3As3 from first-principles calculations

 
 

Hao Jiang, Guanghan Cao, Chao Cao

 
 

The electronic structure of quasi-one-dimensional superconductor K2Cr3As3 is studied through systematic first-principles calculations. The ground state of K2Cr3As3 is …

 
 
 
 
 
 

Coherent and Tunable Terahertz Radiation from Graphene Surface Plasmon Polarirons Excited by Cyclotron Electron Beam

 
 

Tao Zhao, Sen Gong, Min Hu et al.

 
 

Terahertz (THz) radiation can revolutionize modern science and technology. To this date, it remains big challenges to develop intense, coherent and tunable THz radiation sources …

 
 
 
 
 
 

A novel approach combining self-organizing map and parallel factor analysis for monitoring water quality of watersheds under non-point source pollution

 
 

Yixiang Zhang, Xinqiang Liang, Zhibo Wang et al.

 
 

High content of organic matter in the downstream of watersheds underscored the severity of non-point source (NPS) pollution. The major objectives of this study were to …

 
 
 
 
 
 

Point-of-service, quantitative analysis of ascorbic acid in aqueous humor for evaluating anterior globe integrity

 
 

Manas R. Gartia, Santosh K. Misra, Mao Ye et al.

 
 

Limited training, high cost, and low equipment mobility leads to inaccuracies in decision making and is concerning with serious ocular injuries such as suspected ruptured globe …

 
 
 
 
 
 
 
Earth & Environmental Sciences top
 
 
 
 
 
 
 

Rayleigh-wave dispersion reveals crust-mantle decoupling beneath eastern Tibet

 
 

Cédric P. Legendre, Frédéric Deschamps, Li Zhao et al.

 
 

The Tibetan Plateau results from the collision of the Indian and Eurasian Plates during the Cenozoic, which produced at least 2,000 km of convergence. Its tectonics is dominated …

 
 
 
 
 
 

Recurring flood distribution patterns related to short-term Holocene climatic variability

 
 

Gerardo Benito, Mark G. Macklin, Andrei Panin et al.

 
 

Millennial- and multi-centennial scale climate variability during the Holocene has been well documented, but its impact on the distribution and timing of extreme river floods has …

 
 
 
 
 
 

Phase boundary of hot dense fluid hydrogen

 
 

Kenji Ohta, Kota Ichimaru, Mari Einaga et al.

 
 

We investigated the phase transformation of hot dense fluid hydrogen using static high-pressure laser-heating experiments in a laser-heated diamond anvil cell. The results show …

 
 
 
 
 
 

Accelerated CO2 transport on surface of AgO nanoparticles in ionic liquid BMIMBF4

 
 

Dahye Ji, Yong Soo Kang, Sang Wook Kang

 
 

The AgO nanoparticles were utilized for a CO2 separation membrane. The AgO nanoparticles were successfully generated in ionic liquid 1-butyl-3-methyl imidazolium …

 
 
 
 
 
 

Ratiometric and colorimetric near-infrared sensors for multi-channel detection of cyanide ion and their application to measure β-glucosidase

 
 

Panfei Xing, Yongqian Xu, Hongjuan Li et al.

 
 

A near-infrared sensor for cyanide ion (CN) was developed via internal charge transfer (ICT). This sensor can selectively detect CN either through dual-ratiometric fluorescence …

 
 
 
 
 
 

Protection of soil carbon within macro-aggregates depends on intra-aggregate pore characteristics

 
 

Alexandra N. Kravchenko, Wakene C. Negassa, Andrey K. Guber et al.

 
 

Soil contains almost twice as much carbon (C) as the atmosphere and 5–15% of soil C is stored in a form of particulate organic matter (POM). Particulate organic matter C is …

 
 
 
 
 
 

Global effects of agriculture on fluvial dissolved organic matter

 
 

Daniel Graeber, Iola G. Boëchat, Francisco Encina-Montoya et al.

 
 

Agricultural land covers approximately 40% of Earth’s land surface and affects hydromorphological, biogeochemical and ecological characteristics of fluvial networks. In the …

 
 
 
 
 
 

Simultaneous effective carbon and nitrogen removals and phosphorus recovery in an intermittently aerated membrane bioreactor integrated system

 
 

Yun-Kun Wang, Xin-Rong Pan, Yi-Kun Geng et al.

 
 

Recovering nutrients, especially phosphate resource, from wastewater have attracted increasing interest recently. Herein, an intermittently aerated membrane bioreactor (MBR) with …

 
 
 
 
 
 

Unusual Deep Water sponge assemblage in South China—Witness of the end-Ordovician mass extinction

 
 

Lixia Li, Hongzhen Feng, Dorte Janussen et al.

 
 

There are few sponges known from the end-Ordovician to early-Silurian strata all over the world, and no records of sponge fossils have been found yet in China during this …

 
 
 
 
 
 

The spatial distribution, accumulation and potential source of seldom monitored trace elements in sediments of Three Gorges Reservoir, China

 
 

Lanfang Han, Bo Gao, Huaidong Zhou et al.

 
 

The alteration of hydrologic condition of Three Gorges Reservoir (TGR) after impoundment has caused numerous environmental changes. This study investigated the distribution, …

 
 
 
 
 
 

Impacts of El Niño Southern Oscillation and Indian Ocean Dipole on dengue incidence in Bangladesh

 
 

Shahera Banu, Yuming Guo, Wenbiao Hu et al.

 
 

Dengue dynamics are driven by complex interactions between hosts, vectors and viruses that are influenced by environmental and climatic factors. Several studies examined the role …

 
 
 
 
 
 

Barnyard grasses were processed with rice around 10000 years ago

 
 

Xiaoyan Yang, Dorian Q Fuller, Xiujia Huan et al.

 
 

Rice (Oryza sativa) is regarded as the only grass that was selected for cultivation and eventual domestication in the Yangtze basin of China. Although both macro-fossils and …

 
 
 
 
 
 

Bioaggregate of photo-fermentative bacteria for enhancing continuous hydrogen production in a sequencing batch photobioreactor

 
 

Guo-Jun Xie, Bing-Feng Liu, Rui-Qing Wang et al.

 
 

Hydrogen recovery through solar-driven biomass conversion by photo-fermentative bacteria (PFB) has been regarded as a promising way for sustainable energy production. However, a …

 
 
 
 
 
 

Assessing Connectivity Between an Overlying Aquifer and a Coal Seam Gas Resource Using Methane Isotopes, Dissolved Organic Carbon and Tritium

 
 

Charlotte P. Iverach, Dioni I. Cendón, Stuart I. Hankin et al.

 
 

Coal seam gas (CSG) production can have an impact on groundwater quality and quantity in adjacent or overlying aquifers. To assess this impact we need to determine the background …

 
 
 
 
 
 

Forest soil carbon is threatened by intensive biomass harvesting

 
 

David L. Achat, Mathieu Fortin, Guy Landmann et al.

 
 

Forests play a key role in the carbon cycle as they store huge quantities of organic carbon, most of which is stored in soils, with a smaller part being held in vegetation. While …

 
 
 
 
 
 

Highly sensitive image-derived indices of water-stressed plants using hyperspectral imaging in SWIR and histogram analysis

 
 

David M. Kim, Hairong Zhang, Haiying Zhou et al.

 
 

The optical signature of leaves is an important monitoring and predictive parameter for a variety of biotic and abiotic stresses, including drought. Such signatures derived from …

 
 
 
 
 
 

What Has Caused Desertification in China?

 
 

Qi Feng, Hua Ma, Xuemei Jiang et al.

 
 

Desertification is the result of complex interactions among various factors, including climate change and human activities. However, previous research generally focused on either …

 
 
 
 
 
 

Coastal sea level projections with improved accounting for vertical land motion

 
 

Guoqi Han, Zhimin Ma, Nan Chen et al.

 
 

Regional and coastal mean sea level projections in the Intergovernmental Panel for Climate Change (IPCC) Fifth Assessment Report (AR5) account only for vertical land motion (VLM) …

 
 
 
 
 
 

A novel approach combining self-organizing map and parallel factor analysis for monitoring water quality of watersheds under non-point source pollution

 
 

Yixiang Zhang, Xinqiang Liang, Zhibo Wang et al.

 
 

High content of organic matter in the downstream of watersheds underscored the severity of non-point source (NPS) pollution. The major objectives of this study were to …

 
 
 
 
 
 

Crude oil as a microbial seed bank with unexpected functional potentials

 
 

Man Cai, Yong Nie, Chang-Qiao Chi et al.

 
 

It was widely believed that oil is a harsh habitat for microbes because of its high toxicity and hydrophobicity. However, accumulating evidence has revealed the presence of live …

 
 
 
 
 
 

Carbon mineralization pathways and bioturbation in coastal Brazilian sediments

 
 

Cintia O. Quintana, Maurício Shimabukuro, Camila O. Pereira et al.

 
 

Carbon mineralization processes and their dependence on environmental conditions (e.g. through macrobenthic bioturbation) have been widely studied in temperate coastal sediments, …

 
 
 
 
 
 

Bio-grout based on microbially induced sand solidification by means of asparaginase activity

 
 

Mengmeng Li, Qing-Long Fu, Qiuzhuo Zhang et al.

 
 

Bio-grout, a new ground improvement method, has been recently developed to improve the mechanical properties, decrease the permeability of porous materials, reinforce or repair …

 
 
 
 
 
 
 
Health Sciences top
 
 
 
 
 
 
 

Impact of Visual Impairment and Eye diseases on Mortality: the Singapore Malay Eye Study (SiMES)

 
 

Rosalynn Grace Siantar, Ching-Yu Cheng, Chui Ming Gemmy Cheung et al.

 
 

We investigated the relationship of visual impairment (VI) and age-related eye diseases with mortality in a prospective, population-based cohort study of 3,280 Malay adults aged …

 
 
 
 
 
 

Association of Pre-Operative Albuminuria with Post-Operative Outcomes after Coronary Artery Bypass Grafting

 
 

Lekha K. George, Miklos Z. Molnar, Jun L. Lu et al.

 
 

The effect on post-operative outcomes after coronary artery bypass graft(CABG) surgery is not clear. Among 17,812 patients who underwent CABG during October 1,2006-September …

 
 
 
 
 
 

Electric Ablation with Irreversible Electroporation (IRE) in Vital Hepatic Structures and Follow-up Investigation

 
 

Xinhua Chen, Zhigang Ren, Tongyin Zhu et al.

 
 

Irreversible electroporation (IRE) with microsecond-pulsed electric fields (μsPEFs) can effectively ablate hepatocellular carcinomas in animal models. This preclinical study …

 
 
 
 
 
 

Neuroprotection and immunomodulation by xenografted human mesenchymal stem cells following spinal cord ventral root avulsion

 
 

Thiago B. Ribeiro, Adriana S. S. Duarte, Ana Leda F. Longhini et al.

 
 

The present study investigates the effects of xenotransplantation of Adipose Tissue Mesenchymal Stem Cells (AT-MSCs) in animals after ventral root avulsion. AT-MSC has similar …

 
 
 
 
 
 

Plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-AII isoforms

 
 

Kazufumi Honda, Michimoto Kobayashi, Takuji Okusaka et al.

 
 

We recently reported that circulating apolipoprotein AII (apoAII) isoforms apoAII-ATQ/AT (C-terminal truncations of the apoAII homo-dimer) decline significantly in pancreatic …

 
 
 
 
 
 

SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α

 
 

Qilin Ao, Wenjing Su, Shuang Guo et al.

 
 

Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific …

 
 
 
 
 
 

Excess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia

 
 

Tongshuai Zhang, Shaohong Fang, Cong Wan et al.

 
 

High salt diet (HSD) is one of the most important risk factors that contribute to many vascular diseases including ischemic stroke. One proposed mechanism underlying the …

 
 
 
 
 
 

A preclinical evaluation of an autologous living hyaline-like cartilaginous graft for articular cartilage repair: a pilot study

 
 

Yvonne Peck, Pengfei He, Geetha Soujanya V. N. Chilla et al.

 
 

In this pilot study, an autologous synthetic scaffold-free construct with hyaline quality, termed living hyaline cartilaginous graft (LhCG), was applied for treating cartilage …

 
 
 
 
 
 

Tea polyphenols as an antivirulence compound Disrupt Quorum-Sensing Regulated Pathogenicity of Pseudomonas aeruginosa

 
 

Honging Yin, Yifeng Deng, Huafu Wang et al.

 
 

Green tea, a water extract of non-fermented leaves of Camellia sinensis L., is one of the nonalcoholic beverages in China. It is becoming increasingly popular worldwide, because …

 
 
 
 
 
 

Ratiometric and colorimetric near-infrared sensors for multi-channel detection of cyanide ion and their application to measure β-glucosidase

 
 

Panfei Xing, Yongqian Xu, Hongjuan Li et al.

 
 

A near-infrared sensor for cyanide ion (CN) was developed via internal charge transfer (ICT). This sensor can selectively detect CN either through dual-ratiometric fluorescence …

 
 
 
 
 
 

Mitochondria-related miR-141-3p contributes to mitochondrial dysfunction in HFD-induced obesity by inhibiting PTEN

 
 

Juan Ji, Yufeng Qin, Jing Ren et al.

 
 

Mitochondria-related microRNAs (miRNAs) have recently emerged as key regulators of cell metabolism and can modulate mitochondrial fusion and division. In order to investigate the …

 
 
 
 
 
 

Dual ligand/receptor interactions activate urothelial defenses against uropathogenic E. coli

 
 

Yan Liu, Sylvie Mémet, Ricardo Saban et al.

 
 

During urinary tract infection (UTI), the second most common bacterial infection, dynamic interactions take place between uropathogenic E. coli (UPEC) and host urothelial cells. …

 
 
 
 
 
 

Role of genetic mutations in folate-related enzyme genes on Male Infertility

 
 

Kang Liu, Ruizhe Zhao, Min Shen et al.

 
 

Several studies showed that the genetic mutations in the folate-related enzyme genes might be associated with male infertility; however, the results were still inconsistent. We …

 
 
 
 
 
 

Microsphere integrated microfluidic disk: synergy of two techniques for rapid and ultrasensitive dengue detection

 
 

Samira Hosseini, Mohammad M. Aeinehvand, Shah M. Uddin et al.

 
 

The application of microfluidic devices in diagnostic systems is well-established in contemporary research. Large specific surface area of microspheres, on the other hand, has …

 
 
 
 
 
 

Biological and immunotoxicity evaluation of antimicrobial peptide-loaded coatings using a layer-by-layer process on titanium

 
 

Jue Shi, Yu Liu, Ying Wang et al.

 
 

The prevention and control of peri-implantitis is a challenge in dental implant surgery. Dental implants with sustained antimicrobial coating are an ideal way of preventing …

 
 
 
 
 
 

Albumin administration prevents neurological damage and death in a mouse model of severe neonatal hyperbilirubinemia

 
 

Simone Vodret, Giulia Bortolussi, Andrea B. Schreuder et al.

 
 

Therapies to prevent severe neonatal unconjugated hyperbilirubinemia and kernicterus are phototherapy and, in unresponsive cases, exchange transfusion, which has significant …

 
 
 
 
 
 

Interaction between SLC6A4 promoter variants and childhood trauma on the age at onset of bipolar disorders

 
 

B. Etain, M. Lajnef, A. Henrion et al.

 
 

Age at onset (AAO) of bipolar disorders (BD) could be influenced both by a repeat length polymorphism (5HTTLPR) in the promoter region of the serotonin transporter gene (SLC6A4) …

 
 
 
 
 
 

Dental pulp-derived stem cell conditioned medium reduces cardiac injury following ischemia-reperfusion

 
 

Satoshi Yamaguchi, Rei Shibata, Noriyuki Yamamoto et al.

 
 

Stem cells from human exfoliated deciduous teeth (SHEDs) can regenerate various tissues. We investigated the impact of SHED-conditioned medium (SHED-CM) on myocardial injury in a …

 
 
 
 
 
 

Preventive effect of oral goshajinkigan on chronic oxaliplatin-induced hypoesthesia in rats

 
 

Toru Kono, Yasuyuki Suzuki, Keita Mizuno et al.

 
 

Oxaliplatin, a widely used chemotherapeutic agent, induces peripheral neuropathy that manifests itself as two distinct phases: acute cold hyperesthesia and chronic peripheral …

 
 
 
 
 
 

Proximal segmentation of the dorsal mesogastrium reveals new anatomical implications for laparoscopic surgery

 
 

Daxing Xie, Chun Gao, An Lu et al.

 
 

Generally, the gold standard of radical surgery for gastrointestinal (GI) tumors is en bloc resection of primary lesions and their related tissues. For gastric cancer, the ideal …

 
 
 
 
 
 

Clinical efficacy of early loading versus conventional loading of dental implants

 
 

Yanfei Zhu, Xinyi Zheng, Guanqi Zeng et al.

 
 

The aim of this study was to determine the clinical differences between early and conventional loading protocols for dental implants. A comprehensive search of the Medline, …

 
 
 
 
 
 

The effect of vitamin D supplementation on insulin and glucose metabolism in overweight and obese individuals: systematic review with meta-analysis

 
 

Małgorzata Jamka, Małgorzata Woźniewicz, Jan Jeszka et al.

 
 

The aim of this systematic review was to assess the effect of vitamin D supplementation on glucose and insulin metabolism in overweight and obese subjects. The search process was …

 
 
 
 
 
 

Pachychoroid neovasculopathy and age-related macular degeneration

 
 

Masahiro Miyake, Sotaro Ooto, Kenji Yamashiro et al.

 
 

Pachychoroid neovasculopathy is a recently proposed clinical entity of choroidal neovascularization (CNV). As it often masquerades as neovascular age-related macular degeneration …

 
 
 
 
 
 

Alcohol consumption and the risk of Barrett’s esophagus: a comprehensive meta-analysis

 
 

Lin-Lin Ren, Ting-Ting Yan, Zhen-Hua Wang et al.

 
 

Several studies have been proposed to investigate the association between alcohol consumption and risk of Barrett’s esophagus (BE), but as of yet, no quantitative summary of the …

 
 
 
 
 
 

Pregnancy diabetes: A comparison of diagnostic protocols based on point-of-care, routine and optimized laboratory conditions

 
 

Sjoerd A. A. van den Berg, Monique J. M. de Groot, Lorenzo P. W. Salden et al.

 
 

In vitro glycolysis poses a problem during diabetes screening, especially in remote laboratories. Point-of-care analysis (POC) may provide an alternative. We compared POC, …

 
 
 
 
 
 

Nuclear PKM2 contributes to gefitinib resistance via upregulation of STAT3 activation in colorectal cancer

 
 

Qiong Li, Daoxiang Zhang, Xiaoying Chen et al.

 
 

Gefitinib (Iressa, ZD-1839), a small molecule tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR) pathway, is currently under investigation in clinical …

 
 
 
 
 
 

Neutralization of Japanese Encephalitis Virus by heme-induced broadly reactive human monoclonal antibody

 
 

Nimesh Gupta, Mélissanne de Wispelaere, Maxime Lecerf et al.

 
 

Geographical expansion and re-emerging new genotypes of the Japanese encephalitis virus (JEV) require the development of novel therapeutic approaches. Here, we studied a …

 
 
 
 
 
 

Effect of Regular Exercise on Inflammation Induced by Drug-resistant Staphylococcus aureus 3089 in ICR mice

 
 

Jong-Kook Lee, Tudor Luchian, Yoonkyung Park

 
 

Obesity is often associated with irregular dietary habits and reduced physical activity. Regular exercise induces a metabolic response that includes increased expression of …

 
 
 
 
 
 

Brain size regulations by cbp haploinsufficiency evaluated by in-vivo MRI based volumetry

 
 

Juan C. Ateca-Cabarga, Alejandro Cosa, Vicente Pallarés et al.

 
 

The Rubinstein-Taybi Syndrome (RSTS) is a congenital disease that affects brain development causing severe cognitive deficits. In most cases the disease is associated with …

 
 
 
 
 
 

Targeted, noninvasive blockade of cortical neuronal activity

 
 

Nathan McDannold, Yongzhi Zhang, Chanikarn Power et al.

 
 

Here we describe a novel method to noninvasively modulate targeted brain areas through the temporary disruption of the blood-brain barrier (BBB) via focused ultrasound, enabling …

 
 
 
 
 
 

Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery

 
 

Anupam Pradhan, Geoffrey H. Siwo, Naresh Singh et al.

 
 

The spread of Plasmodium falciparum multidrug resistance highlights the urgency to discover new targets and chemical scaffolds. Unfortunately, lack of experimentally validated …

 
 
 
 
 
 

Targeting extra-oral bitter taste receptors modulates gastrointestinal motility with effects on satiation

 
 

Bert Avau, Alessandra Rotondo, Theo Thijs et al.

 
 

Bitter taste receptors (TAS2Rs) are present in extra-oral tissues, including gut endocrine cells. This study explored the presence and mechanism of action of TAS2R agonists on …

 
 
 
 
 
 

A high risk of osteosarcoma in individuals who are homozygous for the p.D104N in endostatin

 
 

Wen-Zhi Bi, Dian-Wei Li, Song Luo et al.

 
 

The D104N polymorphism (p.D104N) in endostatin has been previously identified in many types of cancer, and this polymorphism is believed to be a phenotypic modulator in some …

 
 
 
 
 
 

Fine-tuning of synaptic upscaling at excitatory synapses by endocannabinoid signaling is mediated via the CB1 receptor

 
 

Yunping Song, Jian Zhang, Chu Chen

 
 

The endocannabinoid 2-arachidonoylglycerol (2-AG) functions as a retrograde signaling molecule mediating synaptic transmission and plasticity at both inhibitory and excitatory …

 
 
 
 
 
 

Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity

 
 

Frederic Boal, Jessica Roumegoux, Chiara Alfarano et al.

 
 

The increasing incidence of obesity accentuates the importance of identifying mechanisms and optimal therapeutic strategies for patients with heart failure (HF) in relation to …

 
 
 
 
 
 

(Z)3,4,5,4′-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level

 
 

Xing-Xing Fan, Xiao-Jun Yao, Su Wei Xu et al.

 
 

Calcium is a second messenger which is required for regulation of many cellular processes. However, excessive elevation or prolonged activation of calcium signaling would lead to …

 
 
 
 
 
 

Insights into immune responses in oral cancer through proteomic analysis of saliva and salivary extracellular vesicles

 
 

Flavia V. Winck, Ana Carolina Prado Ribeiro, Romênia Ramos Domingues et al.

 
 

The development and progression of oral cavity squamous cell carcinoma (OSCC) involves complex cellular mechanisms that contribute to the low five-year survival rate of …

 
 
 
 
 
 

Capsular Outcomes Differ with Capsulorhexis Sizes after Pediatric Cataract Surgery: A Randomized Controlled Trial

 
 

Haotian Lin, Xuhua Tan, Zhuoling Lin et al.

 
 

Capsular outcomes of anterior/posterior capsulorhexis opening (ACO/PCO) are essential for performing a secondary in-the-bag intraocular lens implantation. To compare the capsular …

 
 
 
 
 
 

MiR-146a-5p suppresses activation and proliferation of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis through directly targeting Wnt1 and Wnt5a

 
 

Jinghua Du, Xuemin Niu, Yang Wang et al.

 
 

Nonalcoholic fibrosing steatohepatitis is a uniform process throughout nonalcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) have been suggested to modulate cellular …

 
 
 
 
 
 

Habitual Sleep Duration and Risk of Childhood Obesity: Systematic Review and Dose-response Meta-analysis of Prospective Cohort Studies

 
 

Huijuan Ruan, Pengcheng Xun, Wei Cai et al.

 
 

A meta-analysis of cross-sectional studies found that shorter-time sleep was correlated with increased risk of obesity in children. However, findings from prospective cohort …

 
 
 
 
 
 

Prediction of Long-term Post-operative Testosterone Replacement Requirement Based on the Pre-operative Tumor Volume and Testosterone Level in Pituitary Macroadenoma

 
 

Cheng-Chi Lee, Chung-Ming Chen, Shih-Tseng Lee et al.

 
 

Non-functioning pituitary macroadenomas (NFPAs) are the most prevalent pituitary macroadenomas. One common symptom of NFPA is hypogonadism, which may require long-term hormone …

 
 
 
 
 
 

IDH mutation status is associated with a distinct hypoxia/angiogenesis transcriptome signature which is non-invasively predictable with rCBV imaging in human glioma

 
 

Philipp Kickingereder, Felix Sahm, Alexander Radbruch et al.

 
 

The recent identification of IDH mutations in gliomas and several other cancers suggests that this pathway is involved in oncogenesis; however effector functions are complex and …

 
 
 
 
 
 

Subclinical decelerations during developing hypotension in preterm fetal sheep after acute on chronic lipopolysaccharide exposure

 
 

Christopher A. Lear, Joanne O. Davidson, Robert Galinsky et al.

 
 

Subclinical (shallow) heart rate decelerations occur during neonatal sepsis, but there is limited information on their relationship with hypotension or whether they occur before …

 
 
 
 
 
 

Wnt/β-catenin coupled with HIF-1α/VEGF signaling pathways involved in galangin neurovascular unit protection from focal cerebral ischemia

 
 

Chuanhong Wu, Jianxin Chen, Chang Chen et al.

 
 

Microenvironmental regulation has become a promising strategy for complex disease treatment. The neurovascular unit (NVU), as the key structural basis to maintain an optimal …

 
 
 
 
 
 

Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients

 
 

Wei Liu, Shukuan Ling, Weijia Sun et al.

 
 

The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC), and testify whether the selected …

 
 
 
 
 
 

Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting

 
 

Nirmala Bhoo-Pathy, Helena Marieke Verkooijen, Ern-Yu Tan et al.

 
 

Up to 25% of breast cancer patients in Asia present with de novo metastatic disease. We examined the survival trends of Asian patients with metastatic breast cancer over fifteen …

 
 
 
 
 
 

Eryptosis Indices as a Novel Predictive Parameter for Biocompatibility of Fe3O4 Magnetic Nanoparticles on Erythrocytes

 
 

Qian Ran, Yang Xiang, Yao Liu et al.

 
 

Fe3O4 magnetic nanoparticles (Fe3O4-MNPs) have been widely used in clinical diagnosis. Hemocompatibility of the nanoparticles is usually evaluated by hemolysis. However, …

 
 
 
 
 
 

N-acetylcysteine inhibits in vivo oxidation of native low-density lipoprotein

 
 

Yuqi Cui, Chandrakala A. Narasimhulu, Lingjuan Liu et al.

 
 

Low-density lipoprotein (LDL) is non-atherogenic, while oxidized LDL (ox-LDL) is critical to atherosclerosis. N-acetylcysteine (NAC) has anti-atherosclerotic effect with largely …

 
 
 
 
 
 

Screening and Molecular Analysis of Single Circulating Tumor Cells Using Micromagnet Array

 
 

Yu-Yen Huang, Peng Chen, Chun-Hsien Wu et al.

 
 

Immunomagnetic assay has been developed to detect rare circulating tumor cells (CTCs), which shows clinical significance in cancer diagnosis and prognosis. The generation and …

 
 
 
 
 
 

Inhibition of actin polymerization in the NAc shell inhibits morphine-induced CPP by disrupting its reconsolidation

 
 

Gongying Li, Yanmei Wang, Min Yan et al.

 
 

Drug-associated contextual cues contribute to drug craving and relapse after abstinence, which is a major challenge to drug addiction treatment. Previous studies showed that …

 
 
 
 
 
 

Age-associated changes in rich-club organisation in autistic and neurotypical human brains

 
 

Takamitsu Watanabe, Geraint Rees

 
 

Macroscopic structural networks in the human brain have a rich-club architecture comprising both highly inter-connected central regions and sparsely connected peripheral regions. …

 
 
 
 
 
 

Impacts of El Niño Southern Oscillation and Indian Ocean Dipole on dengue incidence in Bangladesh

 
 

Shahera Banu, Yuming Guo, Wenbiao Hu et al.

 
 

Dengue dynamics are driven by complex interactions between hosts, vectors and viruses that are influenced by environmental and climatic factors. Several studies examined the role …

 
 
 
 
 
 

Lactobacillus rhamnosus GG Lysate Increases Re-Epithelialization of Keratinocyte Scratch Assays by Promoting Migration

 
 

Walaa Mohammedsaeed, Sheena Cruickshank, Andrew J. McBain et al.

 
 

A limited number of studies have investigated the potential of probiotics to promote wound healing in the digestive tract. The aim of the current investigation was to determine …

 
 
 
 
 
 

Emergence of Hemagglutinin Mutations During the Course of Influenza Infection

 
 

Anna Cushing, Amanda Kamali, Mark Winters et al.

 
 

Influenza remains a significant cause of disease mortality. The ongoing threat of influenza infection is partly attributable to the emergence of new mutations in the influenza …

 
 
 
 
 
 

Novel genes associated with lymph node metastasis in triple negative breast cancer

 
 

Andrea Mathe, Michelle Wong-Brown, Brianna Morten et al.

 
 

Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype with the worst prognosis and no targeted treatments. TNBC patients are more likely to develop …

 
 
 
 
 
 

CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs

 
 

Yonggang Zhang, Chaoran Yin, Ting Zhang et al.

 
 

Current antiretroviral therapy does not eliminate the integrated and transcriptionally silent HIV-1 provirus in latently infected cells. Recently, a “shock and kill” strategy has …

 
 
 
 
 
 

Statistical Approach to Decreasing the Error Rate of Noninvasive Prenatal Aneuploid Detection caused by Maternal Copy Number Variation

 
 

Han Zhang, Yang-Yu Zhao, Jing Song et al.

 
 

Analyses of cell-free fetal DNA (cff-DNA) from maternal plasma using massively parallel sequencing enable the noninvasive detection of feto-placental chromosome aneuploidy; this …

 
 
 
 
 
 

Targeted DNA Sequencing Detects Mutations Related to Susceptibility among Familial Non-medullary Thyroid Cancer

 
 

Yang Yu, Li Dong, Dapeng Li et al.

 
 

Some studies have demonstrated that familial non-medullary thyroid cancer (FNMTC) has a more aggressive clinical behavior compared to sporadic NMTC (SNMTC). However, FNMTC is …

 
 
 
 
 
 

Injecting vascular endothelial growth factor into the temporomandibular joint induces osteoarthritis in mice

 
 

Pei Shen, ZiXian Jiao, Ji Si Zheng et al.

 
 

It is unclear whether vascular endothelial growth factor (VEGF) can initiate osteoarthritis (OA) in the temporomandibular joint (TMJ). In this study we evaluated the effects of …

 
 
 
 
 
 

Circulating miR-106a is a Novel Prognostic and Lymph Node Metastasis Indicator for Cholangiocarcinoma

 
 

Qingbao Cheng, Feiling Feng, Lumin Zhu et al.

 
 

Cholangiocarcinoma (CCA) is a common biliary malignancy. Despite continuing advances, novel indicators are urgently needed to identify patients with a poor prognosis. Several …

 
 
 
 
 
 

CD44 deficiency inhibits unloading-induced cortical bone loss through downregulation of osteoclast activity

 
 

Yuheng Li, Guohui Zhong, Weijia Sun et al.

 
 

The CD44 is cellular surface adhesion molecule that is involved in physiological processes such as hematopoiesis, lymphocyte homing and limb development. It plays an important …

 
 
 
 
 
 

Identification and functional analysis of novel FZD4 mutations in Han Chinese with familial exudative vitreoretinopathy

 
 

Ping Fei, Xiong Zhu, Zhilin Jiang et al.

 
 

Familial exudative vitreoretinopathy (FEVR) is a hereditary eye disease characterized by defects in the development of retinal vessels. However, known genetic mutations can only …

 
 
 
 
 
 

Stroma-associated master regulators of molecular subtypes predict patient prognosis in ovarian cancer

 
 

Shengzhe Zhang, Ying Jing, Meiying Zhang et al.

 
 

High-grade serous ovarian carcinoma (HGS-OvCa) has the lowest survival rate among all gynecologic cancers and is hallmarked by a high degree of heterogeneity. The Cancer Genome …

 
 
 
 
 
 

Dual subcellular compartment delivery of doxorubicin to overcome drug resistant and enhance antitumor activity

 
 

Yan-feng Song, Dao-zhou Liu, Ying Cheng et al.

 
 

In order to overcome drug resistant and enhance antitumor activity of DOX, a new pH-sensitive micelle (DOX/DQA-DOX@DSPE-hyd-PEG-AA) was prepared to simultaneously deliver DOX to …

 
 
 
 
 
 

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

 
 

Andre L. Samson, Lining Ju, Hyun Ah Kim et al.

 
 

The Open Field (OF) test is one of the most commonly used assays for assessing exploratory behaviour and generalised locomotor activity in rodents. Nevertheless, the vast …

 
 
 
 
 
 

H2S, a novel gasotransmitter, involves in gastric accommodation

 
 

Ailin Xiao, Hongjuan Wang, Xin Lu et al.

 
 

H2S is produced mainly by two enzymes:cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE), using L-cysteine (L-Cys) as the substrate. In this study, we investigated …

 
 
 
 
 
 

No effect on pharmacokinetics of tamoxifen and 4-hydroxytamoxifen by multiple doses of red clover capsule in rats

 
 

Kanumuri Siva Rama Raju, Isha Taneja, Guru Raghavendra Valicherla et al.

 
 

Tamoxifen is used in clinical practice for breast cancer patients and to prevent osteoporosis. Red clover (Trifolium pratense) preparations are consumed worldwide as dietary …

 
 
 
 
 
 

Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like “nightmares” in rats

 
 

Bin Yu, Su-Ying Cui, Xue-Qiong Zhang et al.

 
 

Posttraumatic nightmares are a core component of posttraumatic stress disorder (PTSD) and mechanistically linked to the development and maintenance of this disorder, but little …

 
 
 
 
 
 

Administration of defined microbiota is protective in a murine Salmonella infection model

 
 

Sarah-Lynn E. Martz, Julie A. K. McDonald, Jun Sun et al.

 
 

Salmonella typhimurium is a major cause of diarrhea and causes significant morbidity and mortality worldwide, and perturbations of the gut microbiota are known to increase …

 
 
 
 
 
 

Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease

 
 

Wenjing Zeng, Wen Shan, Lili Gao et al.

 
 

The inflammatory mediator high-mobility group box 1 (HMGB1) plays a critical role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the regulation of …

 
 
 
 
 
 

Neurotoxicity induced by zinc oxide nanoparticles: age-related differences and interaction

 
 

Lei Tian, Bencheng Lin, Lei Wu et al.

 
 

This study mainly investigated the neurotoxicity induced by zinc oxide nanoparticle (ZnO NP) in different-aged mice and the interaction between age and ZnO NP exposure. Sixty …

 
 
 
 
 
 

Effect of traditional Chinese exercise on the quality of life and depression for chronic diseases: a meta-analysis of randomised trials

 
 

Xueqiang Wang, Yanling Pi, Binglin Chen et al.

 
 

Traditional Chinese exercise (TCE) has many uses in the prevention and treatment of chronic diseases. However, there is no consensus regarding the benefit of TCE for chronic …

 
 
 
 
 
 

The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis

 
 

Inga Patarčić, Andrea Gelemanović, Mirna Kirin et al.

 
 

Host genetic factors have frequently been implicated in respiratory infectious diseases, often with inconsistent results in replication studies. We identified 386 studies from …

 
 
 
 
 
 

Transgenerational Developmental Programming of Ovarian Reserve

 
 

C. E. Aiken, J. L. Tarry-Adkins, S. E. Ozanne

 
 

Exposure to an adverse early-life environment leads to long-term health problems, many of which are recapitulated in subsequent generations. The female reproductive tract is …

 
 
 
 
 
 

13C-tryptophan breath test detects increased catabolic turnover of tryptophan along the kynurenine pathway in patients with major depressive disorder

 
 

Toshiya Teraishi, Hiroaki Hori, Daimei Sasayama et al.

 
 

Altered tryptophan–kynurenine (KYN) metabolism has been implicated in major depressive disorder (MDD). The l-[1-13C]tryptophan breath test (13C-TBT) is a noninvasive, …

 
 
 
 
 
 

Family history of esophageal cancer increases the risk of esophageal squamous cell carcinoma

 
 

Tiantian Chen, Hongwei Cheng, Xingdong Chen et al.

 
 

A population-based case-control was performed to explore familial aggregation of esophageal squamous cell carcinoma (ESCC). Family history of cancer was assessed by a structured …

 
 
 
 
 
 

Comparison between Ultrasound Guided Transperineal and Transrectal Prostate Biopsy: A Prospective, Randomized, and Controlled Trial

 
 

Le-Hang Guo, Rong Wu, Hui-Xiong Xu et al.

 
 

This prospective study of comparing transperineal prostate biopsy (TPBx) with transrectal prostate biopsy (TRBx) was aimed to provide evidence for clinicians to select the …

 
 
 
 
 
 

Adrenergic stimulation sensitizes TRPV1 through upregulation of cystathionine β-synthetase in a rat model of visceral hypersensitivity

 
 

Liyan Zhu, Liting Zhao, Ruobing Qu et al.

 
 

The pathogenesis of pain in irritable bowel syndrome (IBS) is poorly understood and treatment remains difficult. The present study was designed to investigate roles of adrenergic …

 
 
 
 
 
 

NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis

 
 

Colin A. Bretz, Sara R. Savage, Megan E. Capozzi et al.

 
 

The objective of this study was to determine the role of individual NFAT isoforms in TNFα-induced retinal leukostasis. To this end, human retinal microvascular endothelial cells …

 
 
 
 
 
 

The Plasmodium palmitoyl-S-acyl-transferase DHHC2 is essential for ookinete morphogenesis and malaria transmission

 
 

Jorge M. Santos, Jessica Kehrer, Blandine Franke-Fayard et al.

 
 

The post-translational addition of C-16 long chain fatty acids to protein cysteine residues is catalysed by palmitoyl-S-acyl-transferases (PAT) and affects the affinity of a …

 
 
 
 
 
 

Epithelial cell-derived micro RNA-146a generates interleukin-10-producing monocytes to inhibit nasal allergy

 
 

Xi Luo, Miaomiao Han, Jianqi Liu et al.

 
 

The aberrant immunity plays an important role in the pathogenesis of allergic diseases. Micro RNAs (miR) are involved in regulating the immunity in the body. This study aims to …

 
 
 
 
 
 

E. adenophorum induces Cell Cycle Arrest and Apoptosis of Splenocytes through the Mitochondrial Pathway and Caspase Activation in Saanen Goats

 
 

Yajun He, Quan Mo, Yanchun Hu et al.

 
 

The precise cytotoxicity of E. Adenophorum in relation to the cell cycle and apoptosis of splenocytes in Saanen goats remains unclear. In the present study, 16 Saanen goats were …

 
 
 
 
 
 

Proteomic profiling of host-biofilm interactions in an oral infection model resembling the periodontal pocket

 
 

Kai Bao, Georgios N. Belibasakis, Nathalie Selevsek et al.

 
 

Periodontal infections cause inflammatory destruction of the tooth supporting tissues. We recently developed a dynamic, in vitro periodontal organotypic tissue model in a …

 
 
 
 
 
 

Genetic variants of SLC17A1 are associated with cholesterol homeostasis and hyperhomocysteinaemia in Japanese men

 
 

Teruhide Koyama, Daisuke Matsui, Nagato Kuriyama et al.

 
 

Hyperuricaemia is an undisputed and highly predictive biomarker for cardiovascular risk. SLC17A1, expressed in the liver and kidneys, harbours potent candidate single nucleotide …

 
 
 
 
 
 

Identification of the active components in Bone Marrow Soup: a mitigator against irradiation-injury to salivary glands

 
 

Dongdong Fang, Shen Hu, Younan Liu et al.

 
 

In separate studies, an extract of soluble intracellular contents from whole bone marrow cells, named “Bone Marrow (BM) Soup”, was reported to either improve cardiac or salivary …

 
 
 
 
 
 

Point-of-service, quantitative analysis of ascorbic acid in aqueous humor for evaluating anterior globe integrity

 
 

Manas R. Gartia, Santosh K. Misra, Mao Ye et al.

 
 

Limited training, high cost, and low equipment mobility leads to inaccuracies in decision making and is concerning with serious ocular injuries such as suspected ruptured globe …

 
 
 
 
 
 
 
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